Lignans from the rhizomes of Iris tectorum

被引：8
作者：
Zhang, Chun-Lei [1 ,2 ,3 ]
Wang, Yan [2 ,3 ]
Liu, Yan-Fei [2 ,3 ]
Liang, Dong [2 ,3 ]
Hao, Zhi-You [2 ,3 ]
Luo, Huan [2 ,3 ]
Chen, Ruo-Yun [2 ,3 ]
Yu, De-Quan [2 ,3 ]
机构：
[1] China Pharmaceut Univ, Jiangsu Prov Key Lab TCM Evaluat & Translat Dev, Sch TCM, Nanjing 211198, Jiangsu, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, 2 Nan Wei Rd, Beijing 100050, Peoples R China
来源：
FITOTERAPIA | 2016年 / 108卷
关键词：
Iris tectorum; Lignans; Racemic mixtures; Sesquineolignan; Cytotoxicity; IRIDAL-TYPE TRITERPENOIDS; STEREOISOMERS; CONSTITUENTS; GLYCOSIDES; NEOLIGNANS;
D O I：
10.1016/j.fitote.2015.11.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (la), (75,7,5,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7,12,8S,8'S,7 '' S,8 '' S)-threo-neo-olivil-4'-O-8-guaiacylglycerol ether (3), together with six known ones (4-9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which were verified by chiral HPLC analysis, compound 3 was a new sesquineolignan. The structures were elucidated on the basis of extensive spectroscopic analysis. To our knowledge, this is the first report of lignan constituents isolated from L tectorum. All compounds were evaluated for their cytotoxicity against five human tumor cell lines and none of them displayed significant toxicity in tested cell lines at a concentration of 10 mu M. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：93 / 97
页数：5
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