Lignans from the rhizomes of Iris tectorum

被引：8

作者：

Zhang, Chun-Lei ^{[1
,2
,3
]}

Wang, Yan ^{[2
,3
]}

Liu, Yan-Fei ^{[2
,3
]}

Liang, Dong ^{[2
,3
]}

Hao, Zhi-You ^{[2
,3
]}

Luo, Huan ^{[2
,3
]}

Chen, Ruo-Yun ^{[2
,3
]}

Yu, De-Quan ^{[2
,3
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Prov Key Lab TCM Evaluat & Translat Dev, Sch TCM, Nanjing 211198, Jiangsu, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, 2 Nan Wei Rd, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2016年 / 108卷

关键词：

Iris tectorum; Lignans; Racemic mixtures; Sesquineolignan; Cytotoxicity; IRIDAL-TYPE TRITERPENOIDS; STEREOISOMERS; CONSTITUENTS; GLYCOSIDES; NEOLIGNANS;

D O I：

10.1016/j.fitote.2015.11.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (la), (75,7,5,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7,12,8S,8'S,7 '' S,8 '' S)-threo-neo-olivil-4'-O-8-guaiacylglycerol ether (3), together with six known ones (4-9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which were verified by chiral HPLC analysis, compound 3 was a new sesquineolignan. The structures were elucidated on the basis of extensive spectroscopic analysis. To our knowledge, this is the first report of lignan constituents isolated from L tectorum. All compounds were evaluated for their cytotoxicity against five human tumor cell lines and none of them displayed significant toxicity in tested cell lines at a concentration of 10 mu M. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：93 / 97

页数：5

共 24 条

[1] ASYMMETRIC-SYNTHESIS OF "3-METHYL-2-PHENYL-1,4-BENZODIOXANES - ABSOLUTE-CONFIGURATION OF THE NEOLIGNANS EUSIDERIN AND EUSIDERIN-C AND EUSIDERIN-D [J].

ARNOLDI, A ;

MERLINI, L .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (12) :2555-2557

[2] Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior [J].

Chen, DF ;

Zhang, SX ;

Chen, K ;

Zhou, BN ;

Wang, P ;

Cosentino, LM ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (11) :1066-1068

[3]

China Pharmacopoeia Committee, 2005, CHIN PHARM, V1, P28

[4] Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans [J].

Duan, Lin ;

Tao, Hong-Wen ;

Hao, Xiao-Jiang ;

Gu, Qian-Qun ;

Zhu, Wei-Ming .

PLANTA MEDICA, 2009, 75 (11) :1241-1245

[5] Lignans isolated from Campylotropis hirtella (Franch.) Schindl. decreased prostate specific antigen and androgen receptor expression in LNCaP cells [J].

Han, Hui-Ying ;

Wang, Xiang-Hong ;

Wang, Nai-Li ;

Ling, Ming-Tat ;

Wong, Yong-Chuan ;

Yao, Xin-Sheng .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (16) :6928-6935

[6] The cytotoxicity of 8-O-4′ neolignans from the seeds of Crataegus pinnatifida [J].

Huang, Xiao-Xiao ;

Zhou, Chen-Chen ;

Li, Ling-Zhi ;

Li, Fei-Fei ;

Lou, Li-Li ;

Li, Dian-Ming ;

Ikejima, Takshi ;

Peng, Ying ;

Song, Shao-Jiang .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (20) :5599-5604

[7] Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells by lignans isolated from Euonymus alatus leaves and twigs [J].

Jeong, Eun Ju ;

Cho, Jung Hee ;

Sung, Sang Hyun ;

Kim, Sun Yeou ;

Kim, Young Choong .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (08) :2283-2286

[8] Studies on the constituents of Swertia japonica MAKINO II.1) -: On the structures of new glycosides [J].

Kikuchi, M ;

Kikuchi, M .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (01) :48-51

[9] Bioactive Lignans from the Rhizomes of Acorus gramineus [J].

Kim, Ki Hyun ;

Kim, Ho Kyung ;

Choi, Sang Un ;

Moon, Eunjung ;

Kim, Sun Yeou ;

Lee, Kang Ro .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (10) :2187-2192

[10] Two New Stereoisomers of Neolignan and Lignan from the Flower Buds of Magnolia fargesii [J].

Lee, Jun ;

Seo, Eun-Kyoung ;

Jang, Dae Sik ;

Ha, Tae Joung ;

Kim, Jong-Pyung ;

Nam, Joo-Won ;

Bae, Green ;

Lee, Yuri Mi ;

Yang, Min Suk ;

Kim, Jin Sook .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (03) :298-301

← 1 2 3 →