Infection phase is a predictor of pruritus in patients with hepatitis B virus infection

被引：2

作者：

Oeda, Satoshi ^{[1
]}

Takahashi, Hirokazu ^{[2
]}

Isoda, Hiroshi ^{[2
]}

Komukai, Sho ^{[3
]}

Imajo, Kento ^{[4
]}

Yoneda, Masato ^{[4
]}

Ono, Masafumi ^{[5
]}

Hyogo, Hideyuki ^{[6
]}

Kawaguchi, Takumi ^{[7
]}

Fujii, Hideki ^{[8
,9
]}

Kawanaka, Miwa ^{[10
]}

Sumida, Yoshio ^{[11
]}

Tanaka, Saiyu ^{[12
]}

Kawamoto, Hirofumi ^{[10
]}

Torimura, Takuji ^{[7
]}

Saibara, Toshiji ^{[5
]}

Kawaguchi, Atsushi ^{[13
]}

Nakajima, Atsushi ^{[4
]}

Eguchi, Yuichiro ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Liver Ctr, Saga, Saga 8498501, Japan

[2] Saga Univ, Fac Med, Div Metab & Endocrinol, 5-1-1 Nabeshima, Saga, Saga 8498501, Japan

[3] Osaka Univ, Grad Sch Med, Dept Integrated Med, Div Biomed Stat, Suita, Osaka 5650817, Japan

[4] Yokohama City Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Yokohama, Kanagawa 2360004, Japan

[5] Kochi Med Sch, Dept Gastroenterol & Hepatol, Nankoku, Kochi 7838505, Japan

[6] JA Hiroshima Gen Hosp, Dept Gastroenterol & Hepatol, Hatsukaichi, Hiroshima 7388503, Japan

[7] Kurume Univ, Sch Med, Div Gastroenterol, Dept Med, Kurume, Fukuoka 8300011, Japan

[8] Osaka City Juso Hosp, Dept Gastroenterol & Hepatol, Osaka, Osaka 5320034, Japan

[9] Osaka City Univ, Grad Sch Med, Dept Hepatol, Osaka, Osaka 5458585, Japan

[10] Kawasaki Med Sch, Gen Med Ctr, Dept Gen Internal Med, Okayama, Okayama 7008505, Japan

[11] Aichi Med Univ, Dept Internal Med, Div Hepatol & Pancreatol, Nagakute, Aichi 4801195, Japan

[12] Nara City Hosp, Ctr Digest & Liver Dis, Nara, Nara 6308305, Japan

[13] Saga Univ, Fac Med, Ctr Comprehens Community Med, Sect Clin Cooperat Syst, Saga, Saga 8498501, Japan

来源：

BIOMEDICAL REPORTS | 2019年 / 11卷 / 02期

关键词：

hepatitis B; pruritus; itching; dermatology; propensity score; SIMPLE NONINVASIVE INDEX; QUALITY-OF-LIFE; PAPULAR ACRODERMATITIS; SIGNIFICANT FIBROSIS; LIVER-DISEASE; LICHEN-PLANUS; MANIFESTATIONS; MANAGEMENT; CHILDHOOD;

D O I：

10.3892/br.2019.1224

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pruritus is a common pathogenesis in liver diseases, including chronic hepatitis B (CHB). The phases of hepatitis B virus (HBV) infection are defined in the American Association for the Study of Liver Diseases guidelines. However, it still remains unclear whether the phase independently affects pruritus. The aim of this study was to clarify the effect of HBV infection phase on pruritus in patients with HBV. Of the 1,631 patients that attended the joint research facilities and were interviewed regarding their pruritus between January and June 2016, 196 patients with HBV infection were selected for the present analysis. One-to-one propensity score-matching using 13 variables was performed between participants in the hepatitis B e antigen (HBe-Ag)-positive/negative immune-active phase group and the inactive CHB phase group. Data from 47 patients per group were included in the final analysis. The prevalence of pruritus in the inactive CHB phase was significantly lower than in the HBe-Ag-positive/negative immune-active phase (23 vs. 47%; P=0.031). Being in the inactive CHB phase was determined to be an independent risk factor for pruritus (odds ratio, 0.35; 95% confidence interval, 0.143-0.842; P=0.019). The progression to inactive CHB phase may contribute to the amelioration of pruritus in patients with HBV infection.

引用

页码：63 / 69

页数：7

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