Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

被引：53

作者：

Gliozzi, Micaela ^{[1
]}

Musolino, Vincenzo ^{[1
]}

Bosco, Francesca ^{[1
]}

Scicchitano, Miriam ^{[1
]}

Scarano, Federica ^{[1
]}

Nucera, Saverio ^{[1
]}

Zito, Maria Caterina ^{[1
]}

Ruga, Stefano ^{[1
]}

Carresi, Cristina ^{[1
]}

Macri, Roberta ^{[1
]}

Guarnieri, Lorenza ^{[1
]}

Maiuolo, Jessica ^{[1
]}

Tavernese, Annamaria ^{[2
]}

Coppoletta, Anna Rita ^{[1
]}

Nicita, Caterina ^{[1
]}

Mollace, Rocco ^{[1
]}

Palma, Ernesto ^{[1
]}

Muscoli, Carolina ^{[1
,3
]}

Belzung, Catherine ^{[4
]}

Mollace, Vincenzo ^{[1
,3
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, Catanzaro, Italy

[2] Univ Hosp Policlin Tor Vergata, Div Cardiol, Rome, Italy

[3] IRCCS San Raffaele Pisana, Via Valcannuta, Rome, Italy

[4] Univ Tours, INSERM, UMR 1253 iBrain, Tours, France

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 163卷

关键词：

Cholesterol homeostasis; Neurological diseases; Lipoproteins; miRNAs; Oxysterols; Cardiovascular risk factors; HIGH-DENSITY-LIPOPROTEIN; LIVER-X-RECEPTOR; AMYLOID-BETA-PEPTIDE; CENTRAL-NERVOUS-SYSTEM; ACUTE REGULATORY PROTEIN; MITOCHONDRIA-ASSOCIATED MEMBRANES; DIET-INDUCED HYPERCHOLESTEROLEMIA; MYOCARDIAL ISCHEMIA-REPERFUSION; SERUM TOTAL CHOLESTEROL; FATTY-ACID-METABOLISM;

D O I：

10.1016/j.phrs.2020.105215

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid hormones and bile acids and the need of trafficking lipids destined to cell metabolism. In particular, it has been recognized that peripheral and central nervous system cholesterol metabolism are separated by the blood brain barrier and are regulated independently; indeed, peripherally, it depends on the balance between dietary intake and hepatic synthesis on one hand and its degradation on the other, whereas in central nervous system it is synthetized de novo to ensure brain physiology. In view of this complex metabolism and its relevant functions in mammalian, impaired levels of cholesterol can induce severe cellular dysfunction leading to metabolic, cardiovascular and neurodegenerative diseases. The aim of this review is to clarify the role of cholesterol homeostasis in health and disease highlighting new intriguing aspects of the cross talk between its central and peripheral metabolism.

引用

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