Place cells and long-term potentiation in the hippocampus

被引：24
作者：
Cobar, Luis Fernando
Yuan, Li
Tashiro, Ayumu
机构：
[1] Nanyang Technol Univ, Sch Biol Sci, Warwick NTU Neurosci Programme, Singapore, Singapore
[2] Univ Warwick, Sch Life Sci, Warwick NTU Neurosci Programme, Warwick, England
来源：
NEUROBIOLOGY OF LEARNING AND MEMORY | 2017年 / 138卷
关键词：
Hippocampus; Place cell; Cognitive map; Synaptic plasticity; Long-term potentiation (LTP); NMDA receptors; COMPLEX-SPIKE CELLS; DEPENDENT PROTEIN-KINASE; FREELY-MOVING RAT; SINGLE UNIT-ACTIVITY; SYNAPTIC PLASTICITY; SPATIAL MEMORY; GRANULE CELLS; GLUTAMATE RECEPTORS; BEHAVING RATS; KNOCKOUT MICE;
D O I：
10.1016/j.nlm.2016.10.010
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Place cells show location-specific firing patterns according to an animal's position in an environment and are thought to contribute to the spatial representation required for self-navigation. Decades of study have extensively characterized the properties of place cells and suggested the involvement of long-term potentiation (LTP), a long-lasting synaptic strengthening, in place cell activity. Here, we review the basic characteristics of place cell activity and the findings that support the idea that LTP contributes to the formation, maintenance, and plasticity of place cell activity. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：206 / 214
页数：9
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