ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

被引:220
作者
Moldogazieva, N. T. [1 ]
Mokhosoev, I. M. [1 ]
Feldman, N. B. [1 ]
Lutsenko, S., V [1 ]
机构
[1] IM Sechenov First Moscow State Med Univ Sechenov, Dept Biotechnol, Moscow, Russia
关键词
Cell signalling; nitrosative protein modification; oxidative protein modification; reactive nitrogen species; reactive oxygen species; redox switches; ROS/RNS signalling; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; HUMAN SERUM-ALBUMIN; THIOREDOXIN-RELATED PROTEIN; SOLUBLE GUANYLATE-CYCLASE; HEPATOCYTE GROWTH-FACTOR; DISULFIDE BOND FORMATION; CYSTEINE SULFENIC ACID; ALPHA-LIPOIC ACID; REACTIVE OXYGEN;
D O I
10.1080/10715762.2018.1457217
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous antioxidant system (AOS) allow reversible oxidative/nitrosative modifications of key redox-sensitive residues in regulatory proteins. The reversibility of redox modifications such as Cys S-sulphenylation/S-glutathionylation/S-nitrosylation/S-persulphidation and disulphide bond formation, or Tyr nitration, which occur through electrophilic attack of RONS to nucleophilic groups in amino acid residues provides redox switches in the activities of signalling proteins. Key requirement for the involvement of the redox modifications in RONS signalling including ROS-MAPK, ROS-PI3K/Akt, and RNS-TNF-alpha/NF-kappa B signalling is their specificity provided by a residue microenvironment and reaction kinetics. Glutathione, glutathione peroxidases, peroxiredoxins, thioredoxin, glutathione reductases, and glutaredoxins modulate RONS level and cell signalling, while some of the modulators (glutathione, glutathione peroxidases and peroxiredoxins) are themselves targets for redox modifications. Additionally, gene expression, activities of transcription factors, and epigenetic pathways are also under redox regulation. The present review focuses on RONS sources (NADPH-oxidases, mitochondrial electron-transportation chain (ETC), nitric oxide synthase (NOS), etc.), and their cross-talks, which influence reversible redox modifications of proteins as physiological phenomenon attained by living cells during the evolution to control cell signalling in the oxygen-enriched environment. We discussed recent advances in investigation of mechanisms of protein redox modifications and adaptive redox switches such as MAPK/PI3K/PTEN, Nrf2/Keapl, and NF-kappa B/I kappa B, powerful regulators of numerous physiological processes, also implicated in various diseases.
引用
收藏
页码:507 / 543
页数:37
相关论文
共 389 条
  • [1] REDOX REGULATION OF FOS AND JUN DNA-BINDING ACTIVITY INVITRO
    ABATE, C
    PATEL, L
    RAUSCHER, FJ
    CURRAN, T
    [J]. SCIENCE, 1990, 249 (4973) : 1157 - 1161
  • [2] Pharmacological and clinical aspects of heme oxygenase
    Abraham, Nader G.
    Kappas, Attallah
    [J]. PHARMACOLOGICAL REVIEWS, 2008, 60 (01) : 79 - 127
  • [3] The function of the respiratory supercomplexes: The plasticity model
    Acin-Perez, Rebeca
    Enriquez, Jose A.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2014, 1837 (04): : 444 - 450
  • [4] Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects
    Acin-Perez, Rebeca
    Salazar, Eric
    Brosel, Sonja
    Yang, Hua
    Schon, Eric A.
    Manfredi, Giovanni
    [J]. EMBO MOLECULAR MEDICINE, 2009, 1 (8-9) : 392 - 406
  • [5] Reactive nitrogen species in cellular signaling
    Adams, Levi
    Franco, Maria C.
    Estevez, Alvaro G.
    [J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 240 (06) : 711 - 717
  • [6] Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling
    Aesif, Scott W.
    Kuipers, Ine
    van der Velden, Jos
    Tully, Jane E.
    Guala, Amy S.
    Anathy, Vikas
    Sheely, Juliana I.
    Reynaert, Niki L.
    Wouters, Emiel F. M.
    van der Vliet, Albert
    Janssen-Heininger, Yvonne M. W.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2011, 51 (06) : 1249 - 1257
  • [7] Sensitizer-mediated photooxidation of histidine residues: Evidence for the formation of reactive side-chain peroxides
    Agon, VV
    Bubb, WA
    Wright, A
    Hawkins, CL
    Davies, MJ
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (04) : 698 - 710
  • [8] Antioxidant therapy for management of oxidative stress induced hypertension
    Ahmad, Khalil Ali
    Yuan, Dai Yuan
    Nawaz, Waqas
    Ze, Hong
    Zhuo, Chen Xue
    Talal, Bashar
    Taleb, Abdoh
    Mais, Enos
    Ding Qilong
    [J]. FREE RADICAL RESEARCH, 2017, 51 (04) : 428 - 438
  • [9] Alberts B.J.A., 2002, Molecular Biology of the Cell - The Mitochondrion, VFourth
  • [10] Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation
    Anand, Puneet
    Hausladen, Alfred
    Wang, Ya-Juan
    Zhang, Guo-Fang
    Stomberski, Colin
    Brunengraber, Henri
    Hess, Douglas T.
    Stamler, Jonathan S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (52) : 18572 - 18577