Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe) What is Optimal Resuscitation?

被引：63

作者：

Osborn, Tiffany M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Sect Acute & Crit Care Surg, 4901 Forest Pk Ave, St Louis, MO 63108 USA

来源：

CRITICAL CARE CLINICS | 2017年 / 33卷 / 02期

关键词：

Severe sepsis; Septic shock; Resuscitation; Usual care; Lactate; Hyperlactatemia; Sepsis; INTERNATIONAL CONSENSUS DEFINITIONS; EMERGENCY-DEPARTMENT PATIENTS; GOAL-DIRECTED THERAPY; SURVIVING SEPSIS; CAMPAIGN GUIDELINES; CLINICAL-CRITERIA; MANAGEMENT; LACTATE; MORTALITY; MULTICENTER;

D O I：

10.1016/j.ccc.2016.12.004

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the United States, Australasian Resuscitation in Sepsis Evaluation (ARISE), and Protocolised Management in Sepsis (ProMISe) in the United Kingdom. All 3 trials confirmed that there was no survival benefit of EGDT compared to usual resuscitation. How should we define usual care for sepsis given these study findings? Furthermore, the definition of sepsis has now been updated. This article reviews key findings of these 3 trials and discusses these important issues in sepsis management.

引用

页码：323 / +

页数：24

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