Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

被引:81
作者
Ashrafizadeh, Milad [1 ]
Hushmandi, Kiavash [2 ]
Rahmani Moghadam, Ebrahim [3 ]
Zarrin, Vahideh [4 ]
Hosseinzadeh Kashani, Sharareh [5 ]
Bokaie, Saied [2 ]
Najafi, Masoud [6 ]
Tavakol, Shima [7 ]
Mohammadinejad, Reza [8 ]
Nabavi, Noushin [9 ]
Hsieh, Chia-Ling [10 ]
Zarepour, Atefeh [11 ]
Zare, Ehsan Nazarzadeh [12 ]
Zarrabi, Ali [13 ,14 ]
Makvandi, Pooyan [15 ,16 ]
机构
[1] Univ Tabriz, Dept Basic Sci, Fac Vet Med, Tabriz 5166616471, Iran
[2] Univ Tehran, Fac Vet Med, Div Epidemiol & Zoonoses, Dept Food Hyg & Qual Control, Tehran 1419963114, Iran
[3] Shiraz Univ Med Sci, Student Res Comm, Sch Med, Dept Anat Sci, Shiraz 7134814336, Iran
[4] Shiraz Univ Med Sci, Lab Stem Cell Res, Shiraz 7134814336, Iran
[5] Islamic Azad Univ, North Tehran Branch, Dept Life Sci, Tehran 1667914161, Iran
[6] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah 6715847141, Iran
[7] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran 1449614525, Iran
[8] Kerman Univ Med Sci, Inst Neuropharmacol, Pharmaceut Res Ctr, Kerman 55425147, Iran
[9] Univ Victoria, Res Serv, Victoria, BC V8W 2Y2, Canada
[10] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei 110, Taiwan
[11] Univ Isfahan, Fac Biol Sci & Technol, Dept Biotechnol, Esfahan 8174673441, Iran
[12] Damghan Univ, Sch Chem, Damghan 3671641167, Iran
[13] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey
[14] Sabanci Univ, Fac Engn & Nat Sci, Ctr Excellence Funct Surfaces & Interfaces EFSUN, TR-34956 Istanbul, Turkey
[15] Ist Italiano Tecnol, Ctr MicrobioRobot, Viale Rinaldo Piaggio 34, I-56025 Pisa, Italy
[16] Shahid Chamran Univ Ahvaz, Fac Sci, Chem Dept, Ahwaz 6153753843, Iran
来源
BIOENGINEERING-BASEL | 2020年 / 7卷 / 03期
关键词
small interfering RNA (siRNA); prostate cancer; gene therapy; nanoparticle; delivery systems; cancer therapy;
D O I
10.3390/bioengineering7030091
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the off-target effects of siRNA therapy remarkably reduce its efficacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The efficacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types.
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页码:1 / 40
页数:40
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