The subcortical maternal complex: multiple functions for one biological structure?

被引:69
作者
Bebbere, D. [1 ]
Masala, L. [1 ]
Albertini, D. F. [2 ,3 ]
Ledda, S. [1 ]
机构
[1] Univ Sassari, Dept Vet Med, Via Vienna 2, I-07100 Sassari, Italy
[2] Ctr Human Reprod, New York, NY 10021 USA
[3] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA
关键词
OOEP/FLOPED; NLRP5/MATER; TLE6; KHDC3/FILIA; Oocyte; Developmental competence; RECURRENT HYDATIDIFORM MOLES; GENE-EXPRESSION; EMBRYONIC-DEVELOPMENT; MESSENGER-RNA; MITOCHONDRIAL-FUNCTION; TRANSLATIONAL CONTROL; REPRODUCTIVE WASTAGE; EFFECT PROTEINS; MOUSE OOCYTE; IN-VITRO;
D O I
10.1007/s10815-016-0788-z
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The subcortical maternal complex (SCMC) is a multiprotein complex uniquely expressed in mammalian oocytes and early embryos, essential for zygote progression beyond the first embryonic cell divisions. Similiar to other factors encoded by maternal effect genes, the physiological role of SCMC remains unclear, although recent evidence has provided important molecular insights into different possible functions. Its potential involvement in human fertility is attracting increasing attention; however, the complete story is far from being told. The present mini review provides an overview of recent findings related to the SCMC and discusses its potential physiological role/s with the aim of inspiring new directions for future research.
引用
收藏
页码:1431 / 1438
页数:8
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