Function, clinical application, and strategies of Pre-mRNA splicing in cancer

被引：68

作者：

Di, Cuixia ^{[1
,2
,3
]}

Syafrizayanti ^{[4
,5
]}

Zhang, Qianjing ^{[1
,2
,3
]}

Chen, Yuhong ^{[1
,2
,3
]}

Wang, Yupei ^{[1
,2
,3
]}

Zhang, Xuetian ^{[1
,2
,3
]}

Liu, Yang ^{[1
,2
]}

Sun, Chao ^{[1
,2
]}

Zhang, Hong ^{[1
,2
]}

Hoheisel, Jorg D. ^{[4
]}

机构：

[1] Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China

[2] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China

[3] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

[4] German Canc Res Ctr, Div Funct Genome Anal, Neuenheimer Feld 580, D-69120 Heidelberg, Germany

[5] Andalas Univ, Fac Math & Nat Sci, Dept Chem, Kampus Limau Manis, Padang, Indonesia

来源：

CELL DEATH AND DIFFERENTIATION | 2019年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

IN-VITRO; BCL-X; ANTISENSE OLIGONUCLEOTIDES; IONIZING-RADIATION; CELL-DEATH; EXPRESSION; RESISTANCE; THERAPY; APOPTOSIS; ISOFORMS;

D O I：

10.1038/s41418-018-0231-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pre-mRNA splicing is a fundamental process that plays a considerable role in generating protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases, especially cancers. In this review, we discuss how aberrant splicing isoforms precisely regulate three basic functional aspects in cancer: proliferation, metastasis and apoptosis. Importantly, clinical function of aberrant splicing isoforms is also discussed, in particular concerning drug resistance and radiosensitivity. Furthermore, this review discusses emerging strategies how to modulate pathologic aberrant splicing isoforms, which are attractive, novel therapeutic agents in cancer. Last we outline current and future directions of isoforms diagnostic methodologies reported so far in cancer. Thus, it is highlighting significance of aberrant splicing isoforms as markers for cancer and as targets for cancer therapy.

引用

页码：1181 / 1194

页数：14

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