Anti-CTLA-4 immunotherapy: uncoupling toxicity and efficacy

被引：17

作者：

Pol, Jonathan ^{[1
,2
,3
,4
]}

Kroemer, Guido ^{[1
,2
,3
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]}

机构：

[1] Ctr Rech Cordeliers, INSERM U1138, Equipe Labelisee Ligue Natl Canc 11, F-75006 Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France

[3] Univ Paris 06, F-75006 Paris, France

[4] Metabol & Cell Biol Platforms, Gustave Roussy Canc Campus, F-94805 Villejuif, France

[5] Hop Europeen Georges Pompidou, Pole Biol, F-75015 Paris, France

[6] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, S-17176 Stockholm, Sweden

来源：

CELL RESEARCH | 2018年 / 28卷 / 05期

关键词：

REGULATORY T-CELLS; CANCER; ANTIBODIES; IPILIMUMAB; MELANOMA; THERAPY;

D O I：

10.1038/s41422-018-0031-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A CTLA-4-specific antibody, ipilimumab, is clinically used in anticancer immunotherapy, yet induces severe autoimmune side effects. Two papers by Du et al. published recently in Cell Research now suggest strategies for potentially uncoupling toxicity and efficacy of CTLA-4-targeting antibodies.

引用

页码：501 / 502

页数：2

共 12 条

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