Targeting the epigenome in hematopoietic malignancies

被引：2
作者：
Jost, E. [1 ]
Osieka, R. [1 ]
Galm, O. [1 ]
机构：
[1] Rhein Westfal TH Aachen, Univ Klinikum Aachen, Med Klin 4, D-52074 Aachen, Germany
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 04期
关键词：
epigenetics; DNA methylation; histone modifications; transcriptional silencing; tumor suppressor genes;
D O I：
10.2174/157018006776743251
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two epigenetic events that are associated with transcriptional silencing in carcinogenesis include hypermethylation of CpG islands near gene promoter regions and changes in chromatin conformation involving histone acetylation. Pharmacologic targeting of these epigenetic processes and upregulation of genes involving fundamental cellular pathways have become a new therapeutic strategy in the treatment of hematopoietic malignancies.
引用
收藏
页码：242 / 252
页数：11
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