Targeting the epigenome in hematopoietic malignancies

被引：2
作者：
Jost, E. [1 ]
Osieka, R. [1 ]
Galm, O. [1 ]
机构：
[1] Rhein Westfal TH Aachen, Univ Klinikum Aachen, Med Klin 4, D-52074 Aachen, Germany
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 04期
关键词：
epigenetics; DNA methylation; histone modifications; transcriptional silencing; tumor suppressor genes;
D O I：
10.2174/157018006776743251
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two epigenetic events that are associated with transcriptional silencing in carcinogenesis include hypermethylation of CpG islands near gene promoter regions and changes in chromatin conformation involving histone acetylation. Pharmacologic targeting of these epigenetic processes and upregulation of genes involving fundamental cellular pathways have become a new therapeutic strategy in the treatment of hematopoietic malignancies.
引用
收藏
页码：242 / 252
页数：11
相关论文
共 150 条
  • [1] Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    Bachman, KE
    Park, BH
    Rhee, I
    Rajagopalan, H
    Herman, JG
    Baylin, SB
    Kinzler, KW
    Vogelstein, B
    [J]. CANCER CELL, 2003, 3 (01) : 89 - 95
  • [2] Bachman KE, 1999, CANCER RES, V59, P798
  • [3] Expression and methylation of CASP8 in neuroblastoma:: Identification of a promoter region
    Banelli, B
    Casciano, I
    Croce, M
    Di Vinci, A
    Gelvi, I
    Pagnan, G
    Brignole, C
    Allemanni, G
    Ferrini, S
    Ponzoni, M
    Romani, M
    [J]. NATURE MEDICINE, 2002, 8 (12) : 1333 - 1335
  • [4] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [5] Phase II study of weekly intravenous recombinant humanized Anti-p185(HER2) monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast
    Baselga, J
    Tripathy, D
    Mendelsohn, J
    Baughman, S
    Benz, CC
    Dantis, L
    Sklarin, NT
    Seidman, AD
    Hudis, CA
    Moore, J
    Rosen, PP
    Twaddell, T
    Henderson, IC
    Norton, L
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) : 737 - 744
  • [6] Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
    Baylin, SB
    Esteller, M
    Rountree, MR
    Bachman, KE
    Schuebel, K
    Herman, JG
    [J]. HUMAN MOLECULAR GENETICS, 2001, 10 (07) : 687 - 692
  • [7] DNA hypermethylation in tumorigenesis - epigenetics joins genetics
    Baylin, SB
    Herman, JG
    [J]. TRENDS IN GENETICS, 2000, 16 (04) : 168 - 174
  • [8] DNA methylation patterns and epigenetic memory
    Bird, A
    [J]. GENES & DEVELOPMENT, 2002, 16 (01) : 6 - 21
  • [9] BOS JL, 1989, CANCER RES, V49, P4682
  • [10] p15INK4B CPG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
    Cameron, EE
    Baylin, SB
    Herman, JG
    [J]. BLOOD, 1999, 94 (07) : 2445 - 2451
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