The Integrated Stress Response in Lung Disease

被引：33

作者：

van 't Wout, Emily F. A. ^{[1
,2
]}

Hiemstra, Pieter S. ^{[1
]}

Marciniak, Stefan J. ^{[2
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden, Netherlands

[2] Univ Cambridge, Dept Med, Cambridge Inst Med Res, Cambridge CB2 0XY, England

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2014年 / 50卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

integrated stress response; lung; endoplasmic reticulum stress; UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM STRESS; CIGARETTE-SMOKE; TRANSCRIPTION FACTOR; CELLULAR STRESS; CHOP; ACTIVATION; FIBROSIS; TRANSLATION; INDUCTION;

D O I：

10.1165/rcmb.2014-0019TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2 alpha by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protect cellular reserves of nutrients and prevents the accumulation of toxic proteins. In this review, we discuss how activation of the integrated stress response has been shown to play an important role in pulmonary pathology, and how its study may help in the development of novel therapies for diverse conditions, from hypoxia to cancer.

引用

页码：1005 / 1009

页数：5

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