Chromosome abnormalities in T-cell acute lymphoblastic leukemia in Korea

被引:3
作者
Park, Joonhong [1 ,2 ]
Kim, Myungshin [1 ,2 ,3 ]
Lee, Hae Kyung [1 ,4 ]
Kim, Yonggoo [1 ,2 ]
Han, Kyungja [1 ,2 ]
Son, Jungok [2 ]
Lee, Seok [5 ]
Chung, Nack-Gyun [6 ]
Cho, Bin [6 ]
机构
[1] Catholic Univ Korea, Dept Lab Med, Coll Med, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Catholic Genet Lab Ctr, Seoul, South Korea
[3] Seoul St Marys Hosp, Dept Lab Med, Seoul 137701, South Korea
[4] Uijeongbu St Marys Hosp, Dept Lab Med, Uijongbu 480130, South Korea
[5] Catholic Univ Korea, Coll Med, Catholic Blood & Marrow Transplantat Ctr, Div Hematol,Dept Internal Med, Seoul, South Korea
[6] Catholic Univ Korea, Coll Med, Dept Pediat, Seoul, South Korea
关键词
T-cell acute lymphoblastic leukemia; Chromosome analysis; Recurrent abnormalities; CLINICAL-SIGNIFICANCE; CYTOGENETIC ABNORMALITIES; ANTIGEN-EXPRESSION; PROGNOSTIC-FACTORS; ISOCHROMOSOME; 17Q; KARYOTYPE; GENE; ASSOCIATION; PRECURSOR; DELETIONS;
D O I
10.1007/s12185-014-1513-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the present study was to analyze chromosome abnormalities in Korean patients with T-cell acute lymphoblastic leukemia (T-ALL). A total of 65 patients with newly diagnosed T-ALL were enrolled in the study from December 2004 to December 2011. Chromosome analysis was performed at diagnosis on short-term cultures of bone marrow specimens. Of these 65 patients, abnormal karyotypes were found in 50 (77 %). Numerical and structural chromosome abnormalities were identified in 16 (25 %) and 47 (72 %) patients, respectively. Deletion was the most common structural abnormality (48 %), followed by translocation (29 %). Overall survival (OS) and relapse-free survival (RFS) outcome were unaffected by the number and/or type of chromosome abnormalities in both childhood and adult T-ALL; however, the OS interval was longer for childhood patients than for adult patients in the entire cohort (P = 0.0003). Similarly, patients with first complete remission (CR) showed a better OS than those who failed to achieve first CR (P < 0.0001). There was a negative clinical impact in adult patients and patients without first CR according to multivariate analysis. This study helps to fill the gap regarding chromosome findings in T-ALL and may lead to identification of the molecular background behind phenotypic differences.
引用
收藏
页码:279 / 287
页数:9
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