Glucosamine Hydrochloride Functionalized Water-Soluble Conjugated Polyfluorene: Synthesis, Characterization, and Interactions with DNA

被引：25

作者：

Chen, Oi ^{[1
]}

Cheng, Qian-Yi ^{[1
,2
]}

Zhao, Yan-Chao ^{[1
,2
]}

Han, Bao-Hang ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2009年 / 30卷 / 19期

基金：

美国国家科学基金会;

关键词：

conjugated polymer; DNA; fluorescence; glucosamine hydrochloride; sensors; SENSITIVE DETECTION; HIGH-EFFICIENCY; GENE DELIVERY; POLYELECTROLYTES; FLUORESCENT; GLYCOPOLYMERS; POLYMERS; PREPOLYMERIZATION; ETHYNYLENE); COMPLEXES;

D O I：

10.1002/marc.200900226

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene was easily synthesized through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. The water-solubility and biocompatibility of the polymer were improved after grarting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single-stranded DNA was studied by spectrofluorometric titration.

引用

页码：1651 / 1655

页数：5

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