Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration

被引：115

作者：

Ishiki, Aiko ^{[1
]}

Kamada, Maki ^{[1
]}

Kawamura, Yuki ^{[1
]}

Terao, Chiaki ^{[1
]}

Shimoda, Fumiko ^{[1
]}

Tomita, Naoki ^{[1
]}

Arai, Hiroyuki ^{[1
]}

Furukawa, Katsutoshi ^{[1
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc, Div Brain Sci, Dept Geriatr & Gerontol, Sendai, Miyagi 9808575, Japan

来源：

JOURNAL OF NEUROCHEMISTRY | 2016年 / 136卷 / 02期

关键词：

Alzheimer's disease; cerebrospinal fluid; dementia with Lewy bodies; frontotemporal lobar degeneration; glial fibrillar acidic protein; DIAGNOSIS; SEVERITY;

D O I：

10.1111/jnc.13399

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarkers in the cerebrospinal fluid (CSF) are currently regarded as indispensable indicators for accurate differential diagnosis of neurodegenerative disorders. Although high levels of astrocyte-secreted glial fibrillar acidic protein (GFAP) in the CSF of patients with Alzheimer's disease (AD) have been reported, the levels of GFAP in the CSF have not been fully investigated in other neurological disorders that cause dementia, such as dementia with Lewy bodies (DLB) and frontotemporal lobar degeneration (FTLD). In this study, we determined the levels of GFAP in the CSF of healthy control subjects and AD, DLB, and FTLD patients to address two questions: (i) Do the levels of GFAP differ among these disorders? and (ii) Can GFAP be used as a biomarker for the differential diagnosis of these neurodegenerative disorders? The levels of GFAP in AD, DLB, and FTLD patients were significantly higher than those in the healthy control subjects. Although the levels of GFAP were not significantly different between AD and DLB patients, a higher level of GFAP was observed in FTLD patients than in AD and DLB patients. It is concluded that representative neurological disorders causing dementia were associated with higher levels of GFAP in the CSF.

引用

页码：258 / 261

页数：4

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