Understanding the Immunological Mechanisms of Mesenchymal Stem Cells in Allogeneic Transplantation: From the Aspect of Major Histocompatibility Complex Class I

被引：37

作者：

Wang, Yafei ^{[1
,2
]}

Tian, Mengya ^{[1
,2
]}

Wang, Fei ^{[1
,2
]}

Heng, Boon Chin ^{[3
]}

Zhou, Jing ^{[1
,2
]}

Cai, Zhijian ^{[4
,5
]}

Liu, Hua ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cells & Reg, Hangzhou 310058, Zhejiang, Peoples R China

[2] Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[3] Peking Univ, Sch Stomatol, Beijing, Peoples R China

[4] Zhejiang Univ, Sch Med, Inst Immunol, Hangzhou, Zhejiang, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 2, Dept Orthoped, Hangzhou, Zhejiang, Peoples R China

来源：

STEM CELLS AND DEVELOPMENT | 2019年 / 28卷 / 17期

基金：

中国国家自然科学基金;

关键词：

mesenchymal stem cells; major histocompatibility complex I; low immunogenicity; stem cell transplantation; immunological rejection; MHC CLASS-I; BONE-MARROW; STROMAL CELLS; NK CELLS; T-CELLS; GRAFT-REJECTION; ADIPOSE-TISSUE; HLA; MOLECULES; EXPRESSION;

D O I：

10.1089/scd.2018.0256

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cell (MSC) transplantation therapy appears to be an ideal strategy for repairing structural defects and restoring the functions of diseased tissues and organs. Additionally, MSCs are also used as immunosuppressants in allogeneic organ transplantation. However, owing to their inherent immunogenicity, MSC transplantation can induce the activation of an immune response, which can lead to the death and clearance of the transplanted MSCs. Major histocompatibility complex (MHC) molecules are responsible for antigen presentation, help T lymphocytes to recognize endogenous/extrinsic antigens, and trigger immune activation. Many studies have shown that MHC molecules (particularly class I) play key roles in the immunogenicity of MSCs. This review, therefore, focuses on the relationship between MHC-I surface expression on MSCs and its immunogenicity, as well as potential strategies to overcome the hurdle of MHC incompatibility.

引用

页码：1141 / 1150

页数：10