Diffuse Large B Cell Lymphoma in Wiskott-Aldrich Syndrome: A Case Report and Review of Literature

被引：9

作者：

Senapati, Jayastu ^{[1
]}

Devasia, Anup J. ^{[1
]}

David, Sachin ^{[1
]}

Manipadam, Marie Therese ^{[2
]}

Nair, Sheila ^{[2
]}

Jayandharan, Giridhara R. ^{[1
]}

George, Biju ^{[1
]}

机构：

[1] Christian Med Coll & Hosp, Dept Clin Haematol, Vellore 632004, Tamil Nadu, India

[2] Christian Med Coll & Hosp, Dept Gen Pathol, Vellore 632004, Tamil Nadu, India

来源：

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2014年 / 30卷

关键词：

Diffuse large B cell lymphoma; Wiskott-Aldrich syndrome; Primary immunodeficiency syndrome; EPSTEIN-BARR-VIRUS; NON-HODGKINS-LYMPHOMA; MALIGNANT-LYMPHOMA; GENE-MUTATIONS; WASP GENE; PATIENT; DISEASE; CHILD;

D O I：

10.1007/s12288-014-0377-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Wiskott-Aldrich syndrome (WAS) is an X linked rare primary immunodeficiency syndrome with an increased propensity for infection, autoimmunity and malignancy. Here we report a male child, who was diagnosed with WAS at 1 year of age following evaluation for symptomatic thrombocytopenia and eczematous skin lesions. He presented later with lymphadenopathy, which was consistent with diffuse large B cell lymphoma on histopathology. He received 6 cycles of R-CHOP chemotherapy for the same and is presently in remission after 6 months. We review the major publications of lymphoma in WAS and discuss the pathological findings, treatment and prognosis of lymphoma in WAS.

引用

页码：S309 / S313

页数：5

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