Role of AhR/ARNT system in skin homeostasis

被引：148
作者：
Furue, Masutaka [1 ,2 ,3 ]
Takahara, Masakazu [1 ]
Nakahara, Takeshi [1 ,3 ]
Uchi, Hiroshi [1 ,2 ]
机构：
[1] Kyushu Univ, Dept Dermatol, Higashi Ku, Fukuoka 8128582, Japan
[2] Kyushu Univ, Res & Clin Ctr Yusho & Dioxin, Fukuoka 8128582, Japan
[3] Kyushu Univ, Div Skin Surface Sensing, Fukuoka 8128582, Japan
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 2014年 / 306卷 / 09期
关键词：
Aryl hydrocarbon receptor; Aryl hydrocarbon receptor nuclear translocator; Dioxin; Malassezia; Melanogenesis; Th17; Treg; Ultraviolet; ARYL-HYDROCARBON RECEPTOR; YEAST MALASSEZIA-FURFUR; EPIDERMAL DIFFERENTIATION COMPLEX; REGULATORY T-CELLS; HUMAN KERATINOCYTES; DIOXIN RECEPTOR; BARRIER FUNCTION; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ALTERS; MOLECULAR-MECHANISMS; CORNIFIED ENVELOPE;
D O I：
10.1007/s00403-014-1481-7
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
引用
收藏
页码：769 / 779
页数：11
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