Role of AhR/ARNT system in skin homeostasis

被引：149
作者：
Furue, Masutaka [1 ,2 ,3 ]
Takahara, Masakazu [1 ]
Nakahara, Takeshi [1 ,3 ]
Uchi, Hiroshi [1 ,2 ]
机构：
[1] Kyushu Univ, Dept Dermatol, Higashi Ku, Fukuoka 8128582, Japan
[2] Kyushu Univ, Res & Clin Ctr Yusho & Dioxin, Fukuoka 8128582, Japan
[3] Kyushu Univ, Div Skin Surface Sensing, Fukuoka 8128582, Japan
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 2014年 / 306卷 / 09期
关键词：
Aryl hydrocarbon receptor; Aryl hydrocarbon receptor nuclear translocator; Dioxin; Malassezia; Melanogenesis; Th17; Treg; Ultraviolet; ARYL-HYDROCARBON RECEPTOR; YEAST MALASSEZIA-FURFUR; EPIDERMAL DIFFERENTIATION COMPLEX; REGULATORY T-CELLS; HUMAN KERATINOCYTES; DIOXIN RECEPTOR; BARRIER FUNCTION; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ALTERS; MOLECULAR-MECHANISMS; CORNIFIED ENVELOPE;
D O I：
10.1007/s00403-014-1481-7
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
引用
收藏
页码：769 / 779
页数：11
相关论文
共 96 条
[31]   The Aryl Hydrocarbon Receptor Mediates UVB Radiation-Induced Skin Tanning [J].
Jux, Bettina ;
Kadow, Stephanie ;
Luecke, Sandra ;
Rannug, Agneta ;
Krutmann, Jean ;
Esser, Charlotte .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (01) :203-210
[32]   Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice [J].
Jux, Bettina ;
Kadow, Stephanie ;
Esser, Charlotte .
JOURNAL OF IMMUNOLOGY, 2009, 182 (11) :6709-6717
[33]   Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis [J].
Kadow, Stephanie ;
Jux, Bettina ;
Zahner, Sonja P. ;
Wingerath, Britta ;
Chmill, Stefanie ;
Clausen, Bjorn E. ;
Hengstler, Jan ;
Esser, Charlotte .
JOURNAL OF IMMUNOLOGY, 2011, 187 (06) :3104-3110
[34]   2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Production of Reactive Oxygen Species Is An Essential Step in the Mechanism of Action to Accelerate Human Keratinocyte Differentiation [J].
Kennedy, Lawrence H. ;
Sutter, Carrie Hayes ;
Carrion, Sandra Leon ;
Tran, Quynh T. ;
Bodreddigari, Sridevi ;
Kensicki, Elizabeth ;
Mohney, Robert P. ;
Sutter, Thomas R. .
TOXICOLOGICAL SCIENCES, 2013, 132 (01) :235-249
[35]   Decrease of reactive oxygen species and reciprocal increase of nitric oxide in human dermal endothelial cells by Bidens pilosa extract: A possible explanation of its beneficial effect on livedo vasculopathy [J].
Kohda, Futoshi ;
Takahara, Masakazu ;
Hachiya, Akiko ;
Takei, Kenjiro ;
Tsuji, Gaku ;
Yamamura, Kazuhiko ;
Furue, Masutaka .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2013, 72 (01) :75-77
[36]   Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur:: Comparison with the bisindolylmaleimide arcyriarubin A [J].
Krämer, HJ ;
Kessler, D ;
Hipler, UC ;
Irlinger, B ;
Hort, W ;
Bödeker, RH ;
Steglich, W ;
Mayser, P .
CHEMBIOCHEM, 2005, 6 (12) :2290-2297
[37]   Malassezin, a novel agonist of the aryl hydrocarbon receptor from the yeast Malassezia furfur, induces apoptosis in primary human melanocytes [J].
Krämer, HJ ;
Podobinska, M ;
Bartsch, A ;
Battmann, A ;
Thoma, W ;
Bernd, A ;
Kummer, W ;
Irlinger, B ;
Steglich, W ;
Mayser, P .
CHEMBIOCHEM, 2005, 6 (05) :860-865
[38]  
Krutmann J, 2012, J INVEST DERMATOL, V132, P976, DOI 10.1038/jid.2011.394
[39]   The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family [J].
Kypriotou, Magdalini ;
Huber, Marcel ;
Hohl, Daniel .
EXPERIMENTAL DERMATOLOGY, 2012, 21 (09) :643-649
[40]   Irradiance, but not fluence, plays a crucial role in UVB-induced immature pigment cell development: new insights for efficient UVB phototherapy [J].
Lan, Cheng-Che E. ;
Yu, Hsin-Su ;
Lu, Jian-He ;
Wu, Ching-Shuang ;
Lai, Hsiao-Chi .
PIGMENT CELL & MELANOMA RESEARCH, 2013, 26 (03) :367-376
12345678910