3-Aroylindoles via Copper-Catalyzed Cyclization of N-(2-Iodoaryl)enaminones

被引：23

作者：

Bernini, Roberta ^{[2
,3
]}

Cacchi, Sandro ^{[1
]}

Fabrizi, Giancarlo ^{[1
]}

Filisti, Eleonora ^{[1
]}

Sferrazza, Alessio ^{[2
,3
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy

[2] Univ Tuscia, Dipartimento ABAC, I-01100 Viterbo, Italy

[3] Consorzio Univ La Chim Ambiente, I-01100 Viterbo, Italy

来源：

SYNLETT | 2009年 / 09期

关键词：

indoles; enaminones; cyclization; copper; catalysis; ACTIVATING-FACTOR ANTAGONISTS; 2,3-DISUBSTITUTED INDOLES; BOND FORMATION; PALLADIUM; ARYLATION; ACYLATION; 3-ACYLINDOLES; ENAMINONES; ELLIPTICINE; PYRROLES;

D O I：

10.1055/s-0029-1216742

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and alpha,beta-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chloro substituents. This indole synthesis can also be carried out from 2-iodoanilines and alpha,beta-ynones through a sequential process that omits the isolation of enaminone intermediates.

引用

页码：1480 / 1484

页数：5

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