Diet components can suppress inflammation and reduce cancer risk

被引:72
作者
Hardman, W. Elaine [1 ]
机构
[1] Marshall Univ, Joan C Edwards Sch Med, Dept Biochem & Microbiol, Huntington, WV 25701 USA
关键词
Cancer; plant based diet; walnut; inflammation; NF kappa B; NF-KAPPA-B; MAMMARY-GLAND TUMORIGENESIS; POLYUNSATURATED FATTY-ACIDS; BREAST-CANCER; PROSTATE-CANCER; DOCOSAHEXAENOIC ACID; ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; BLADDER-CANCER; ADIPOSE-TISSUE;
D O I
10.4162/nrp.2014.8.3.233
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Epidemiology studies indicate that diet or specific dietary components can reduce the risk for cancer, cardiovascular disease and diabetes. An underlying cause of these diseases is chronic inflammation. Dietary components that are beneficial against disease seem to have multiple mechanisms of action and many also have a common mechanism of reducing inflammation, often via the NF kappa B pathway. Thus, a plant based diet can contain many components that reduce inflammation and can reduce the risk for developing all three of these chronic diseases. We summarize dietary components that have been shown to reduce cancer risk and two studies that show that dietary walnut can reduce cancer growth and development. Part of the mechanism for the anticancer benefit of walnut was by suppressing the activation of NF kappa B. In this brief review, we focus on reduction of cancer risk by dietary components and the relationship to suppression of inflammation. However, it should be remembered that most dietary components have multiple beneficial mechanisms of action that can be additive and that suppression of chronic inflammation should reduce the risk for all three chronic diseases.
引用
收藏
页码:233 / 240
页数:8
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