Impact of the enzyme flexibility on the enzyme enantio-selectivity in organic media towards specific and non-specific substrates

被引：18

作者：

Broos, J ^{[1
]}

机构：

[1] Univ Groningen, Dept Biochem, NL-9747 AG Groningen, Netherlands

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2002年 / 20卷 / 04期

关键词：

enzyme enantioselectivity; enzyme flexibility; organic media; specific substrates;

D O I：

10.1080/10242420290004938

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rationale is presented as to why the enantioselectivity of enzymes in dry organic media towards specific substrates is increased when the enzyme flexibility is increased. This is outlined for serine proteases towards N-acetyl-amino acid esters. The reasons why this relationship does not hold in the case of non-specific substrates are discussed.

引用

页码：291 / 295

页数：5

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