Anticancer activity of Ocimum sanctum

被引：31
作者：
Karthikeyan, K
Gunasekaran, P
Ramamurthy, N
Govindasamy, S
机构：
[1] Univ Madras, Dept Biochem & Mol Biol, Madras 600025, Tamil Nadu, India
[2] King Inst Prevent Med, Dept Virol, Madras 600032, Tamil Nadu, India
来源：
PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 04期
关键词：
apoptosis; cytotoxicity; glutathione; human fibrosarcoma cells; Ocimum sanctum extracts; Sarcoma-180 solid tumor;
D O I：
10.1076/phbi.37.4.285.5801
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ocimum sanctum L. (Labiatae), a plant with various medicinal properties, has been investigated against human fibrosarcoma cells (HFS cells) in culture. Treatment with an ethanolic extract of Ocimum sanctum induced cytotoxicity at 50 mu g/ml and above. Morphologically the cells showed shrunken cytoplasm and condensed nuclei. The DNA was found to be fragmented on observation in agarose gel electrophoresis. Biochemically the extract-treated HFS cells showed depleted intracellular glutathione and increased levels of lipid peroxidation products. Administration of aqueous and ethanolic extracts of Ocimum sanctum to mice bearing Sarcoma-180 solid tumors mediated a significant reduction in tumor volume and an increase in lifespan. These observations clearly indicate Ocimum sanctum extracts possess anticancer activity.
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收藏
页码：285 / 290
页数：6
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