Synthesis, in vitro and in silico studies of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)(pyridin-2-yl)methanone and its derivatives

A series of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl) (pyridin-2-yl)methanone and its derivatives (8a-g) was synthesized by the reaction of cis-3-(-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno [3,2-c] pyrazole hydrochloride (7) with substituted picolinic acid (5) in the presence of hexafluorophosphate azabenzotriazole tetramethyl uronium and N,N-diisopropylethylamine. All the compounds were thoroughly characterized by spectral and elemental analysis. They have been screened for their antibacterial activity and docking results of title compounds have been presented.