Synthesis, in vitro and in silico studies of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)(pyridin-2-yl)methanone and its derivatives

被引：0
|
作者：
Marupati, Siddhartha [1 ,2 ]
Eppakayala, Laxminarayana [3 ]
Pagilla, Shankaraiah [2 ]
Dayakar, Gade [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal, Telangana, India
[2] Vardhaman Coll Engn Autonomous, Dept Chem, Hyderabad, Telangana, India
[3] Sreenidhi Inst Sci & Technol Autonomous, Dept Chem, Hyderabad, Telangana, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 30卷 / 03期
关键词：
Pyrazole; Piperazine; Hexafluorophosphate azabenzotriazole tetramethyl uronium; Antibacterial activity; Docking studies; SOLVENT-FREE CONDITIONS; RECEPTOR ANTAGONISTS; PYRAZOLOPYRIDINES; POTENT; INHIBITORS; SAR;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl) (pyridin-2-yl)methanone and its derivatives (8a-g) was synthesized by the reaction of cis-3-(-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno [3,2-c] pyrazole hydrochloride (7) with substituted picolinic acid (5) in the presence of hexafluorophosphate azabenzotriazole tetramethyl uronium and N,N-diisopropylethylamine. All the compounds were thoroughly characterized by spectral and elemental analysis. They have been screened for their antibacterial activity and docking results of title compounds have been presented.
引用
收藏
页码：425 / 432
页数：8
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