The potential clinical applications and prospects of microRNAs in lung cancer

被引：15

作者：

Gao, Ying ^{[1
]}

Gao, Fei ^{[2
]}

Ma, Jin-lu ^{[1
]}

Sun, Wen-ze ^{[1
]}

Song, Li-ping ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Radiotherapy Oncol, Xian 710061, Peoples R China

[2] Xian Med Univ, Affiliated Hosp 1, Dept Neurol, Xian, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2014年 / 7卷

基金：

中国国家自然科学基金;

关键词：

microRNA; lung cancer; biomarker; chemotherapy; radiotherapy; TUMOR-SUPPRESSOR; EXPRESSION; CELLS; SENSITIVITY; RESISTANCE; GROWTH; RADIOSENSITIVITY; CHEMORESISTANCE; PROLIFERATION; PATHOGENESIS;

D O I：

10.2147/OTT.S62227

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lung cancer is the major cause of cancer deaths worldwide due to its late diagnosis and poor outcome. Understanding genomic medicine may widen our vision into the oncogenesis of lung cancer and may open the door to improvements in the clinical management of lung cancer. It is well known that almost half of all genes are regulated by microRNAs (miRNAs). This review focuses on the role of miRNAs in lung cancer and also touches on the value of miRNA-based novel therapies for lung cancers.

引用

页码：901 / 905

页数：5

共 67 条

[51] miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1 [J].

Roybal, Jonathon D. ;

Zang, Yi ;

Ahn, Young-Ho ;

Yang, Yanan ;

Gibbons, Don L. ;

Baird, Brandi N. ;

Alvarez, Cristina ;

Thilaganathan, Nishan ;

Liu, Diane D. ;

Saintigny, Pierre ;

Heymach, John V. ;

Creighton, Chad J. ;

Kurie, Jonathan M. .

MOLECULAR CANCER RESEARCH, 2011, 9 (01) :25-35

[52] Implication of microRNAs in drug resistance for designing novel cancer therapy [J].

Sarkar, Fazlul H. ;

Li, Yiwei ;

Wang, Zhiwei ;

Kong, Dejuan ;

Ali, Shadan .

DRUG RESISTANCE UPDATES, 2010, 13 (03) :57-66

[53] Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro [J].

Sun, Yihua ;

Fang, Rong ;

Li, Chenguang ;

Li, Li ;

Li, Fei ;

Ye, Xiaolei ;

Chen, Haiquan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (02) :501-507

[54] Regression of murine lung tumors by the let-7 microRNA [J].

Trang, P. ;

Medina, P. P. ;

Wiggins, J. F. ;

Ruffino, L. ;

Kelnar, K. ;

Omotola, M. ;

Homer, R. ;

Brown, D. ;

Bader, A. G. ;

Weidhaas, J. B. ;

Slack, F. J. .

ONCOGENE, 2010, 29 (11) :1580-1587

[55] A microRNA expression signature of human solid tumors defines cancer gene targets [J].

Volinia, S ;

Calin, GA ;

Liu, CG ;

Ambs, S ;

Cimmino, A ;

Petrocca, F ;

Visone, R ;

Iorio, M ;

Roldo, C ;

Ferracin, M ;

Prueitt, RL ;

Yanaihara, N ;

Lanza, G ;

Scarpa, A ;

Vecchione, A ;

Negrini, M ;

Harris, CC ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) :2257-2261

[56] Epidermal growth factor receptor-regulated miR-125a-5p-a metastatic inhibitor of lung cancer [J].

Wang, Guofu ;

Mao, Wei-min ;

Zheng, Shu ;

Ye, Jingjia .

FEBS JOURNAL, 2009, 276 (19) :5571-5578

[57] MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14) [J].

Wang, R. ;

Wang, Z-X ;

Yang, J-S ;

Pan, X. ;

De, W. ;

Chen, L-B .

ONCOGENE, 2011, 30 (23) :2644-2658

[58] MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy [J].

Weidhaas, Joanne B. ;

Babar, Lmran ;

Nallur, Sunitha M. ;

Trang, Phong ;

Roush, Sarah ;

Boehm, Nfichelle ;

Gillespie, Erin ;

Slack, Frank J. .

CANCER RESEARCH, 2007, 67 (23) :11111-11116

[59] EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines [J].

Weiss, G. J. ;

Bemis, L. T. ;

Nakajima, E. ;

Sugita, M. ;

Birks, D. K. ;

Robinson, W. A. ;

Varella-Garcia, M. ;

Bunn, P. A., Jr. ;

Haney, J. ;

Helfrich, B. A. ;

Kato, H. ;

Hirsch, F. R. ;

Franklin, W. A. .

ANNALS OF ONCOLOGY, 2008, 19 (06) :1053-1059

[60] Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34 [J].

Wiggins, Jason F. ;

Ruffino, Lynnsie ;

Kelnar, Kevin ;

Omotola, Michael ;

Patrawala, Lubna ;

Brown, David ;

Bader, Andreas G. .

CANCER RESEARCH, 2010, 70 (14) :5923-5930

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