Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine

被引：24

作者：

Huang, Wei ^{[1
]}

Kim, Seong Jong ^{[1
]}

Liu, Joyce ^{[1
]}

Zhang, Wenjun ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 21期

基金：

美国国家卫生研究院;

关键词：

RHIZOCTONIA-LEGUMINICOLA; CASTANOSPERMUM-AUSTRALE; FUNGAL ORIGIN; SYNTHASE; SWAINSONINE; SLAFRAMINE; CHAIN; RING; (1S; 6S; 8AS)-1-ACETOXY-6-AMINOOCTAHYDROINDOLIZINE; METABOLISM;

D O I：

10.1021/acs.orglett.5b02707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.

引用

页码：5344 / 5347

页数：4

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