Relationship between objectively recorded hot flashes and sleep disturbances among breast cancer patients: investigating hot flash characteristics other than frequency

被引:0
作者
Savard, Marie-Helene [1 ,2 ,3 ]
Savard, Josee [1 ,2 ,3 ]
Caplette-Gingras, Aude [1 ,2 ,3 ]
Ivers, Hans [1 ,2 ,3 ]
Bastien, Celyne [1 ,4 ]
机构
[1] Univ Laval, Sch Psychol, Quebec City, PQ G1R 2J6, Canada
[2] Univ Laval, Canc Res Ctr, Quebec City, PQ G1R 2J6, Canada
[3] CHU Quebec, Ctr Rech, Quebec City, PQ, Canada
[4] Univ Laval Robert Giffard, Ctr Rech, Quebec City, PQ, Canada
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2013年 / 20卷 / 10期
基金
加拿大健康研究院;
关键词
Breast cancer; Hot flashes; Quantitative electroencephalogram; Sternal skin conductance; Sleep disturbances; Polysomnography; ESTROGEN REPLACEMENT; INSOMNIA; WOMEN; ASSOCIATION; SYMPTOMS; SURVIVORS; PREVALENCE; ACCURACY; IMPACT;
D O I
10.1097/gme.0b013e3182885e31
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of this study was to evaluate the relationship between various characteristics of objectively recorded hot flashes and sleep disturbances in breast cancer patients. Methods: Fifty-six women who had completed a similar treatment protocol for a first diagnosis of breast cancer within the previous 3 months wore ambulatory sternal skin conductance and polysomnography devices for a home-based nighttime recording of hot flashes and sleep. Results: Hot flash frequency was not associated with polysomnographic variables (r = -0.18 to 0.21) or beta-I and beta-II electroencephalographic activities (r = -0.01 and 0.03) but was significantly correlated with increased slow (r = 0.28) and delta (r = 0.32) electroencephalographic activities. A slower hot flash onset and a longer hot flash duration were associated with greater polysomnographic impairments (r = -0.50 to 0.48). Greater sleep disturbances were found during hot flash onset or hot flash plateau as compared with the pre-hot flash period (greater percentage of wake time, lower percentage of stage II sleep, and lower percentage of rapid eye movement sleep, all P values < 0.05). The probability that a stage change to a lighter sleep occurred was significantly greater during hot flash onset (11%) than during hot flash plateau (6%; P = 0.02). Conclusions: This study suggests that the speed and duration of hot flashes would contribute more importantly to sleep alterations than hot flash frequency. Sleep disturbances tend to occur simultaneously with hot flashes, suggesting that these two nocturnal symptoms are manifestations of a higher-order mechanism involving the central nervous system.
引用
收藏
页码:997 / 1005
页数:9
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