Anti-proliferative Properties of New Variety Organic Rice MRQ74 Extracts against Colon Cancer Cells: In-vitro Study

被引：0

作者：

Rohin, Mohd Adzim Khalili ^{[1
]}

Abd Hadi, Norhayati ^{[1
]}

Ridzwan, Norhaslinda ^{[1
]}

机构：

[1] Univ Sultan Zainal Abidin, Fac Hlth Sci, Sch Nutr & Dietet, Terengganu 21300, Malaysia

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2020年 / 32卷 / 12期

关键词：

Organic rice MRQ74; colon cancer; cytotoxic; MTT assay; AO/PI staining; FERMENTED BROWN RICE; ANTIOXIDANT ACTIVITY; PHENOLIC CONTENT; FERULIC ACID; APOPTOSIS; BRAN; CARCINOGENESIS; SOLVENT; COMPONENTS; INDUCTION;

D O I：

10.9734/JPRI/2020/v32i1230560

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims: To examine the anti-proliferative properties of different extracts of new variety an organic rice MRQ74 towards colon cancer cells: in-vitro study. Study Design: Experimental study. Place and Duration of Study: Central Laboratory, Tissue Culture Laboratory, University of Sultan Zainal Abidin, Terengganu from November 2019 until February 2020. Methodology: The organic rice MRQ74 extracts had been led to tetrazolium salt reduction (MTT) assay and an inhibition concentration of 50 (IC 50) value for their cytotoxic potential against colon cancer cells. Meanwhile, cells morphology observation and fluorescence double staining of treatment cells were determined using a light inverted microscope and acridine orange/propidium iodide staining. Results: Results showed that 50% aqueous ethanol of rice grains gave the lowest IC50 values towards HCT-116 and CT-26 cell lines, while an aqueous solution of rice grains gave the lowest IC50 values towards HT-29 cells (p<0.05). Thoroughly, the treated colon cancer cells had shown morphological alterations after treated with different solvent extracts of an organic rice MRQ74. Conclusion: The outcomes had observed preliminary results on cancer study for better health by inspiring the consumption of an organic rice MRQ74 and future product developments.

引用

页码：55 / 67

页数：13

共 32 条

[21] Aqueous two-phase extraction of phenolic compounds from Sedum dendroideum with antioxidant activity and anti-proliferative properties against breast cancer cells [J].

Enriquez-Ochoa, Daniela ;

Sanchez-Trasvina, Calef ;

Hernandez-Sedas, Betsabe ;

Mayolo-Deloisa, Karla ;

Zavala, Judith ;

Rito-Palomares, Marco ;

Valdez-Garcia, Jorge E. .

SEPARATION AND PURIFICATION TECHNOLOGY, 2020, 251

[22] The Ethanol Extract of Polish Propolis Exhibits Anti-Proliferative and/or Pro-Apoptotic Effect on HCT 116 Colon Cancer and Me45 Malignant Melanoma Cells In Vitro Conditions [J].

Kubina, Robert ;

Kabala-Dzik, Agata ;

Dziedzic, Arkadiusz ;

Bielec, Beata ;

Wojtyczka, Robert D. ;

Buldak, Rafal J. ;

Wyszynska, Magdalena ;

Stawiarska-Pieta, Barbara ;

Szaflarska-Stojko, Ewa .

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 24 (02) :203-212

[23] Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties [J].

Tundis, Rosa ;

Loizzo, Monica R. ;

Bonesi, Marco ;

Peruzzi, Lorenzo ;

Efferth, Thomas .

NATURAL PRODUCT RESEARCH, 2019, 33 (12) :1809-1812

[24] In-Vitro Anti-Proliferative and Pro-Apoptotic Properties of Sutureja Khuzestanica on Human Breast Cancer Cell Line (MCF-7) and Its Synergic Effects with Anticancer Drug Vincristine [J].

Esmaeili-Mahani, Saeed ;

Samandari-Bahraseman, Mohammad Rasoul ;

Yaghoobi, Mohammad Mehdi .

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (01) :343-352

[25] Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells [J].

Lien, Hsiu-Man ;

Kuo, Po-Tsun ;

Huang, Chao-Lu ;

Kao, Jung-Yie ;

Lin, Ho ;

Yang, Ding-Yah ;

Lai, Ya-Yun .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 :1-8

[26] Anti-proliferative and Anti-metastatic Potential of High Molecular Weight Secretory Molecules from Probiotic Lactobacillus Reuteri Cell-Free Supernatant Against Human Colon Cancer Stem-Like Cells (HT29-ShE) [J].

Maghsood, Faezeh ;

Johari, Behrooz ;

Rohani, Mahdi ;

Madanchi, Hamid ;

Saltanatpour, Zohreh ;

Kadivar, Mehdi .

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2020, 26 (04) :2619-2631

[27] Anti-proliferative and Anti-metastatic Potential of High Molecular Weight Secretory Molecules from Probiotic Lactobacillus Reuteri Cell-Free Supernatant Against Human Colon Cancer Stem-Like Cells (HT29-ShE) [J].

Faezeh Maghsood ;

Behrooz Johari ;

Mahdi Rohani ;

Hamid Madanchi ;

Zohreh Saltanatpour ;

Mehdi Kadivar .

International Journal of Peptide Research and Therapeutics, 2020, 26 :2619-2631

[28] In Vitro Selective Anti-Proliferative Effect of Zinc Oxide Nanoparticles Against Co-Cultured C2C12 Myoblastoma Cancer and 3T3-L1 Normal Cells [J].

Chandrasekaran, Murugesan ;

Pandurangan, Muthuraman .

BIOLOGICAL TRACE ELEMENT RESEARCH, 2016, 172 (01) :148-154

[29] Anti-proliferative Effects of Organic Extracts from Root Bark of Juglans Regia L. (RBJR) on MDA-MB-231 Human Breast Cancer Cells: Role of Bcl-2/Bax, Caspases and Tp53 [J].

Hasan, Tarique N. ;

Grace, Leena B. ;

Shafi, Gowhar ;

Al-Hazzani, Amal A. ;

Alshatwi, Ali A. .

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2011, 12 (02) :525-530

[30] Design, synthesis and molecular docking study of new pyrimidine-based hydrazones with selective anti-proliferative activity against MCF-7 and MDA-MB-231 human breast cancer cell lines [J].

Badawi, Waleed A. ;

Samir, Mohamed ;

Fathy, Hazem M. ;

Okda, Tarek M. ;

Noureldin, Mohamed H. ;

Atwa, Gamal M. K. ;

AboulWafa, Omaima M. .

BIOORGANIC CHEMISTRY, 2023, 138

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