Screening of a panel of steroid-related genes showed polymorphisms of aromatase genes confer susceptibility to advanced stage endometriosis in the Taiwanese Han population

被引：10
作者：
Wu, Cheng-Hsuan [1 ,2 ]
Yang, Jyuer-Ger [2 ]
Chang, Yu-Jun [3 ]
Hsu, Chao-Chin [4 ]
Kuo, Pao-Lin [5 ]
机构：
[1] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[2] Changhua Christian Hosp, Dept Obstet & Gynecol, Changhua, Taiwan
[3] Changhua Christian Hosp, Epidemiol & Biostat Ctr, Changhua, Taiwan
[4] Taipei Med Univ, Dept Obstet & Gynecol, Shuang Ho Hosp, New Taipei City 23561, Taiwan
[5] Cheng Kung Univ Hosp, Dept Obstet & Gynecol, Tainan, Taiwan
来源：
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | 2013年 / 52卷 / 04期
关键词：
endometriosis; polymorphism; steroid-related genes; 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 EXPRESSION; PROGESTERONE-RECEPTOR GENE; ASSOCIATION; RISK; DISEASE; CYP17; ESTRADIOL; WOMEN; PATHOPHYSIOLOGY; ADENOMYOSIS;
D O I：
10.1016/j.tjog.2013.10.006
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To establish a multilocus model for studying the effect of steroid-related genes on advanced stage endometriosis. Materials and methods: A total of 121 patients with advanced stage endometriosis and 171 control women were included. Eighteen single-nucleotide polymorphisms (SNPs) from nine genes (HSD17B1, HSD17B2, HSD17B5, HSD17B6, CYP17, CYP19, ER alpha:, ER beta and PGR) were genotyped using the TaqMan assays. Logistic regression models were used to evaluate the genetic effects, with adjustment for other covariates. Results: Only the presence of the mutant CYP19 (aromatase gene) was associated with a significantly increased risk of endometriosis after adjusting for age, BMI, and parity (p = 0.002, OR = 2.69; 95% CI = 1.44-5.02). No association was ascertained between the other investigated SNPs and endometriosis. Conclusion: Polymorphisms of the aromatase gene confer susceptibility to advanced stage endometriosis in the Taiwanese Han population. Copyright 2013, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.
引用
收藏
页码：485 / 492
页数：8
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