Xylogranin B: A Potent Wnt Signal Inhibitory Limonoid from Xylocarpus granatum

被引：30

作者：

Toume, Kazufumi ^{[1
]}

Kamiya, Kentaro ^{[1
]}

Arai, Midori A. ^{[1
]}

Mori, Naomi ^{[1
]}

Sadhu, Samir K. ^{[2
]}

Ahmed, Firoj ^{[3
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan

[2] Khulna Univ, Sch Life Sci, Pharm Discipline, Khulna 9208, Bangladesh

[3] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 23期

基金：

日本学术振兴会;

关键词：

CATENIN; STEREOCHEMISTRY; MUTATIONS; DISEASE;

D O I：

10.1021/ol4029995

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/beta-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased beta-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in beta-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

引用

页码：6106 / 6109

页数：4