RGD-mediated delivery of small-molecule drugs

被引：69
作者：
Katsamakas, Sotirios [1 ]
Chatzisideri, Theodora [2 ]
Thysiadis, Savvas [2 ]
Sarli, Vasiliki [2 ]
机构：
[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Univ Campus, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Dept Chem, Univ Campus, Thessaloniki 54124, Greece
来源：
FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 06期
关键词：
angiogenesis; integrin A(nu)beta(3); RGD conjugates; RGD peptide; targeted drug delivery; tumor therapy; AGGREGATION-INDUCED EMISSION; PEPTIDE-PACLITAXEL CONJUGATE; PLANT ANTITUMOR AGENTS; HUMAN BREAST-CANCER; IN-VIVO EVALUATION; BIOLOGICAL EVALUATION; ALPHA(V)BETA(3) INTEGRIN; TUMOR VASCULATURE; TOPOISOMERASE-I; OVARIAN-CANCER;
D O I：
10.4155/fmc-2017-0008
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to alpha(nu)beta(3), alpha(5)beta(1) and alpha(nu)beta(6) integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.
引用
收藏
页码：579 / 604
页数：26
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