The effective natural compounds for inhibiting Cervical cancer

被引:13
作者
Gokalp, Faik [1 ]
机构
[1] Kirikkale Univ, Educ Fac, Dept Math & Sci Educ, Sci Educ, TR-71450 Kirikkale, Turkey
关键词
P53 carcinoma cell; Docking; Thymol; Carvacrol; Tymoquinone; AUTOPHAGY;
D O I
10.1007/s12032-021-01456-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The secondary compounds found in plants are of great importance in the treatment of many diseases in medicine and pharmacy. Some of these compounds have been reported to exhibit anticarcinogenic effects by inhibiting the growth and metastatic potential of cancer cells. Consumption of the required amount of vegetables and fruits appears to have a protective effect of these secondary compounds on cancer, since most of these drugs are synthesized from natural or natural origin compounds. Secondary compounds in medicinal plants have been found to have an antiproliferative effect by increasing the expression of p53 in cervical cancer cells and decreasing the expression of cyclin D1, one of the cell proliferation markers. The most important step in the fight against cancer is the development of drugs that are selectively targeted against tumor cells and targeting cancer cells to reduce damage to normal cells and prevent the growth and spread of cancer cells. Molecular insertion test is an effective tool for evaluating the bioactivity of possible molecules. In this study, the effect of natural compounds in some medicinal plants in inhibiting cervical cancer, the points where they are effective using docking has been investigated.
引用
收藏
页数:4
相关论文
共 27 条
[1]   Impact of garlic (Allium sativum) oil on cisplatin-induced hepatorenal biochemical and histopathological alterations in rats [J].
Abdel-Daim, Mohamed M. ;
Abdel-Rahman, Haidy G. ;
Dessouki, Amina A. ;
El-Far, Ali H. ;
Khodeer, Dina M. ;
Bin-Jumah, May ;
Alhader, Mosaed S. ;
Alkahtani, Saad ;
Aleya, Lotfi .
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 710
[2]   Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent [J].
Aygun, Aysenur ;
Gulbagca, Fulya ;
Ozer, Lutfiye Yildiz ;
Ustaoglu, Buket ;
Altunoglu, Yasemin Celik ;
Baloglu, Mehmet Cengiz ;
Atalar, Mehmet Nuri ;
Alma, Mehmet Hakki ;
Sen, Fatih .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 179
[3]   Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock [J].
Bikadi, Zsolt ;
Hazai, Eszter .
JOURNAL OF CHEMINFORMATICS, 2009, 1
[4]   IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway [J].
Cai, Hongning ;
Yan, Lin ;
Liu, Nian ;
Xu, Meng ;
Cai, Hongbing .
BIOMEDICINE & PHARMACOTHERAPY, 2020, 123
[5]   Synthesis and evaluation of apoptotic induction of human cancer cells by ester derivatives of thujone [J].
Castner, Emily ;
Dickson, Matthew ;
Mykytyn, Anna ;
Seeram, Navindra P. ;
Henry, Geneive E. ;
Vivekanand, Pavithra .
MEDICINAL CHEMISTRY RESEARCH, 2020, 29 (02) :268-280
[6]   Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice [J].
Choudhari, Amit S. ;
Mandave, Pallavi C. ;
Deshpande, Manasi ;
Ranjekar, Prabhakar ;
Prakash, Om .
FRONTIERS IN PHARMACOLOGY, 2020, 10
[7]   Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective? [J].
Elbe, Hulya ;
Yigitturk, Gurkan ;
Cavusoglu, Turker ;
Baygar, Tuba ;
Onal, Melike ;
Ozturk, Feral .
ULTRASTRUCTURAL PATHOLOGY, 2020, 44 (02) :193-202
[8]   Cervical cancer classification using convolutional neural networks and extreme learning machines [J].
Ghoneim, Ahmed ;
Muhammad, Ghulam ;
Hossain, M. Shamim .
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE, 2020, 102 :643-649
[9]   METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B [J].
Hu, Yingying ;
Li, Youjiang ;
Huang, Yiping ;
Jin, Zujian ;
Wang, Caifeng ;
Wang, Hongsheng ;
Xu, Jian .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 879
[10]   Anticancer activity of thymol: A literature-based review and docking study with Emphasis on its anticancer mechanisms [J].
Islam, Muhammad T. ;
Khalipha, Abul B. R. ;
Bagchi, Rajat ;
Mondal, Milon ;
Smrity, Shanita Z. ;
Uddin, Shaikh J. ;
Shilpi, Jamil A. ;
Rouf, Razina .
IUBMB LIFE, 2019, 71 (01) :9-19