Dendritic cell-based vaccines: From mouse models to clinical cancer immunotherapy

被引：0
作者：
Schreurs, FWJ
Eggert, AAO
Punt, CJA
Figdor, CG
Adema, GJ
机构：
[1] Univ Nijmegen St Radboud Hosp, Dept Tumor Immunol, NL-6525 EX Nijmegen, Netherlands
[2] Univ Nijmegen St Radboud Hosp, Dept Med Oncol, NL-6525 EX Nijmegen, Netherlands
来源：
CRITICAL REVIEWS IN ONCOGENESIS | 2000年 / 11卷 / 01期
关键词：
dendritic cells; tumor; vaccination; cancer; immunotherapy;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
B and T lymphocytes are the effecters of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity.
引用
收藏
页码：1 / 17
页数：17
相关论文
共 133 条
[1]   A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells [J].
Adema, GJ ;
Hartgers, F ;
Verstraten, R ;
deVries, E ;
Marland, G ;
Menon, S ;
Foster, J ;
Xu, YM ;
Nooyen, P ;
McClanahan, T ;
Bacon, KB ;
Figdor, CG .
NATURE, 1997, 387 (6634) :713-717
[2]   Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].
Albert, ML ;
Sauter, B ;
Bhardwaj, N .
NATURE, 1998, 392 (6671) :86-89
[3]   Phenotypic analysis of antigen-specific T lymphocytes [J].
Altman, JD ;
Moss, PAH ;
Goulder, PJR ;
Barouch, DH ;
McHeyzerWilliams, MG ;
Bell, JI ;
McMichael, AJ ;
Davis, MM .
SCIENCE, 1996, 274 (5284) :94-96
[4]   Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse [J].
Anjuère, F ;
Martín, P ;
Ferrero, I ;
Fraga, ML ;
del Hoyo, GM ;
Wright, N ;
Ardavin, C .
BLOOD, 1999, 93 (02) :590-598
[5]   THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION [J].
ARDAVIN, C ;
WU, L ;
LI, CL ;
SHORTMAN, K .
NATURE, 1993, 362 (6422) :761-763
[6]  
ASHLEY DM, 1997, J EXP MED, V186, P117
[7]  
Austyn J M, 1992, Semin Immunol, V4, P227
[8]  
BAKKER ABH, 1995, CANCER RES, V55, P5330
[9]   Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[10]   Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood [J].
Bender, A ;
Sapp, M ;
Schuler, G ;
Steinman, RM ;
Bhardwaj, N .
JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 196 (02) :121-135
12345678910