Red blood cell deformability in multiple myeloma

被引：9
|
作者：
Caimi, Gregorio [1 ]
Carlisi, Melania [1 ]
Montana, Maria [1 ]
Galla, Eleonora [1 ]
Hopps, Eugenia [1 ]
Lo Presti, Rosalia [1 ]
Siragusa, Sergio [1 ]
机构：
[1] Univ Palermo, Dipartmento Biomed Med Interna & Specialist, Palermo, Italy
来源：
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2018年 / 69卷 / 1-2期
关键词：
Multiple myeloma; erythrocyte deformability; microcirculation; NOCTURNAL HEMOGLOBINURIA-PHENOTYPE; ATOMIC-FORCE MICROSCOPY; FATTY-ACID SYNTHASE; HYPERVISCOSITY SYNDROME; IGA MYELOMA; ERYTHROCYTES; POPULATIONS; ANEMIA; PATHOGENESIS; ASSOCIATION;
D O I：
10.3233/CH-189121
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this study was the evaluation of the erythrocyte deformability in multiple myeloma (MM). We enrolled 29 MM patients and we evaluated, on fasting venous blood, the erythrocyte deformability, expressed as elongation index, and examined using the diffractometric method. By comparing normal controls and MM patients, a significant decrease in erythrocyte deformability, especially at low shear stresses, was found. In this research paper we evaluated all the hypothesis for a possible explanation of the behaviour of red blood cell deformability in MM, even considering how the alteration of erythrocyte deformability worsens the microcirculatory flow in these patients in association with the marked increase in plasma viscosity.
引用
收藏
页码：233 / 238
页数：6
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