The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems

被引：60

作者：

Lin, Chia-I. ^{[1
,2
]}

McCarty, Reid M. ^{[1
,2
]}

Liu, Hung-wen ^{[1
,2
]}

机构：

[1] Univ Texas Austin, Div Chem Biol & Med Chem, Coll Pharm, Austin, TX 78731 USA

[2] Univ Texas Austin, Dept Chem, Austin, TX 78731 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 13期

基金：

美国国家卫生研究院;

关键词：

biosynthesis; catalysis; enzymes; name reaction; reaction mechanisms; ANAEROBIC BENZOATE DEGRADATION; METHYLERYTHRITOL PHOSPHATE-PATHWAY; PHENYLALANINE AMMONIA-LYASE; CATALYZED 4+2 CYCLOADDITION; BAEYER-VILLIGER OXIDATION; BIOSYNTHETIC GENE-CLUSTER; DIELS-ALDER REACTION; INDUCED DNA CLEAVAGE; POLYKETIDE SYNTHASE; STRICTOSIDINE SYNTHASE;

D O I：

10.1002/anie.201603291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical reactions that are named in honor of their true, or at least perceived, discoverers are known as "name reactions". This Review is a collection of biological representatives of named chemical reactions. Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical diversity in natural product biosynthesis as well as the parallels with synthetic organic chemistry. An attempt has been made, whenever possible, to describe the enzymatic mechanisms of catalysis within the context of their synthetic counterparts and to discuss the mechanistic hypotheses for those reactions that are currently active areas of investigation. This Review has been categorized by reaction type, for example condensation, nucleophilic addition, reduction and oxidation, substitution, carboxylation, radical-mediated, and rearrangements, which are subdivided by name reactions.

引用

页码：3446 / 3489

页数：44

共 416 条

[81] Specificity and Reactivity in Menaquinone Biosynthesis: The Structure of Escherichia coli MenD (2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexadiene-1-Carboxylate Synthase) [J].