Detection of dengue NS1 antigen using long-range surface plasmon waveguides

被引：54
作者：
Wong, Wei Ru [1 ]
Sekaran, Shamala Devi [2 ]
Adikan, Faisal Rafiq Mahamd [1 ]
Berini, Pierre [3 ,4 ,5 ]
机构：
[1] Univ Malaya, Dept Elect Engn, Integrated Lightwave Res Grp, Fac Engn, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia
[3] Univ Ottawa, Sch Elect Engn & Comp Sci, 800 King Edward Ave, Ottawa, ON K1N 6N5, Canada
[4] Univ Ottawa, Dept Phys, 150 Louis Pasteur, Ottawa, ON K1N 6N5, Canada
[5] Univ Ottawa, Ctr Res Photon, Ottawa, ON K1N 6N5, Canada
来源：
BIOSENSORS & BIOELECTRONICS | 2016年 / 78卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Optical biosensor; Long range surface plasmon polariton; Waveguide; Dengue; Non-structural 1 (NS1) protein; SEROLOGICAL DIAGNOSIS; PRINTED ELECTRODE; VIRUS-INFECTION; PROTEIN; FEVER; SENSOR; NANOPARTICLES; IMMUNOSENSOR; RECOGNITION; SENSITIVITY;
D O I：
10.1016/j.bios.2015.11.030
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The non-structural 1 (NS1) protein of the dengue virus circulates in infected patients' blood samples and can be used for early diagnosis of dengue infection. In this paper, we present the detection of naturally occurring dengue NS1 antigen in infected patient blood plasma using straight long-range surface plasmon waveguides. Three commercially-available anti-NS1 monoclonal antibodies were used for recognition and their performance was compared and discussed. A similar figure of merit to the one used in conventional dengue NS1 capture using an enzyme-linked immunosorbent assay (ELISA) was applied to our results. In general, the positive patient samples can be clearly differentiated from the negative ones and the results agree with those obtained using ELISA. The largest signal-to-noise ratio observed during the experiments was 356 and the best detection limit observed is estimated as 5.73 pg/mm(2). (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：132 / 139
页数：8
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