Emerging Biological Principles of Metastasis

被引：2213
作者：
Lambert, Arthur W. [1 ]
Pattabiraman, Diwakar R. [1 ]
Weinberg, Robert A. [1 ,2 ,3 ]
机构：
[1] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
[3] MIT, Ludwig Ctr Mol Oncol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
来源：
CELL | 2017年 / 168卷 / 04期
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; BREAST-CANCER CELLS; STEM-LIKE CELLS; BONE-MARROW; LUNG ADENOCARCINOMA; T-CELLS; COLLECTIVE INVASION; DISTANT METASTASIS; BRAIN METASTASIS;
D O I：
10.1016/j.cell.2016.11.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
引用
收藏
页码：670 / 691
页数：22
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