Emerging Biological Principles of Metastasis

被引：2213
作者：
Lambert, Arthur W. [1 ]
Pattabiraman, Diwakar R. [1 ]
Weinberg, Robert A. [1 ,2 ,3 ]
机构：
[1] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
[3] MIT, Ludwig Ctr Mol Oncol, 77 Massachusetts Ave, Cambridge, MA 02142 USA
来源：
CELL | 2017年 / 168卷 / 04期
基金：
英国医学研究理事会;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; BREAST-CANCER CELLS; STEM-LIKE CELLS; BONE-MARROW; LUNG ADENOCARCINOMA; T-CELLS; COLLECTIVE INVASION; DISTANT METASTASIS; BRAIN METASTASIS;
D O I：
10.1016/j.cell.2016.11.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
引用
收藏
页码：670 / 691
页数：22
相关论文
共 197 条
  • [1] En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
    Aceto, Nicola
    Toner, Mehmet
    Maheswaran, Shyamala
    Haber, Daniel A.
    [J]. TRENDS IN CANCER, 2015, 1 (01): : 44 - 52
  • [2] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
    Aceto, Nicola
    Bardia, Aditya
    Miyamoto, David T.
    Donaldson, Maria C.
    Wittner, Ben S.
    Spencer, Joel A.
    Yu, Min
    Pely, Adam
    Engstrom, Amanda
    Zhu, Huili
    Brannigan, Brian W.
    Kapur, Ravi
    Stott, Shannon L.
    Shioda, Toshi
    Ramaswamy, Sridhar
    Ting, David T.
    Lin, Charles P.
    Toner, Mehmet
    Haber, Daniel A.
    Maheswaran, Shyamala
    [J]. CELL, 2014, 158 (05) : 1110 - 1122
  • [3] A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
    Acharyya, Swarnali
    Oskarsson, Thordur
    Vanharanta, Sakari
    Malladi, Srinivas
    Kim, Juliet
    Morris, Patrick G.
    Manova-Todorova, Katia
    Leversha, Margaret
    Hogg, Nancy
    Seshan, Venkatraman E.
    Norton, Larry
    Brogi, Edi
    Massague, Joan
    [J]. CELL, 2012, 150 (01) : 165 - 178
  • [4] Models, mechanisms and clinical evidence for cancer dormancy
    Aguirre-Ghiso, Julio A.
    [J]. NATURE REVIEWS CANCER, 2007, 7 (11) : 834 - 846
  • [5] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
    Al-Mehdi, AB
    Tozawa, K
    Fisher, AB
    Shientag, L
    Lee, A
    Muschel, RJ
    [J]. NATURE MEDICINE, 2000, 6 (01) : 100 - 102
  • [6] EMT: 2016
    Angela Nieto, M.
    Huang, Ruby Yun-Ju
    Jackson, Rebecca A.
    Thiery, Jean Paul
    [J]. CELL, 2016, 166 (01) : 21 - 45
  • [7] Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    Baccelli, Irene
    Schneeweiss, Andreas
    Riethdorf, Sabine
    Stenzinger, Albrecht
    Schillert, Anja
    Vogel, Vanessa
    Klein, Corinna
    Saini, Massimo
    Baeuerle, Tobias
    Wallwiener, Markus
    Holland-Letz, Tim
    Hoefner, Thomas
    Sprick, Martin
    Scharpff, Martina
    Marme, Frederik
    Sinn, Hans Peter
    Pantel, Klaus
    Weichert, Wilko
    Trumpp, Andreas
    [J]. NATURE BIOTECHNOLOGY, 2013, 31 (06) : 539 - U143
  • [8] Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    Balic, Marija
    Lin, Henry
    Young, Lillian
    Hawes, Debra
    Giuliano, Armando
    McNamara, George
    Datar, Ram H.
    Cote, Richard J.
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (19) : 5615 - 5621
  • [9] Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    Barkan, Dalit
    Kleinman, Hynda
    Simmons, Justin L.
    Asmussen, Holly
    Kamaraju, Anil K.
    Hoenorhoff, Mark J.
    Liu, Zi-yao
    Costes, Sylvain V.
    Cho, Edward H.
    Lockett, Stephen
    Khanna, Chand
    Chambers, Ann F.
    Green, Jeffrey E.
    [J]. CANCER RESEARCH, 2008, 68 (15) : 6241 - 6250
  • [10] Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment
    Barkan, Dalit
    El Touny, Lara H.
    Michalowski, Aleksandra M.
    Smith, Jane Ann
    Chu, Isabel
    Davis, Anne Sally
    Webster, Joshua D.
    Hoover, Shelley
    Simpson, R. Mark
    Gauldie, Jack
    Green, Jeffrey E.
    [J]. CANCER RESEARCH, 2010, 70 (14) : 5706 - 5716
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