Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection

被引：36
|
作者：
Loucera, Carlos [1 ,2 ]
Esteban-Medina, Marina [1 ,2 ]
Rian, Kinza [1 ]
Falco, Matias M. [1 ,2 ,3 ]
Dopazo, Joaquin [1 ,2 ,3 ,4 ]
Pena-Chilet, Maria [1 ,2 ,3 ]
机构：
[1] Hosp Virgen del Rocio, Clin Bioinformat Area, FPS, CDCA, Seville 41013, Spain
[2] Hosp Virgen del Rocio, Inst Biomed Seville IBIS, Computat Syst Med, Seville 41013, Spain
[3] Hosp Virgen del Rocio, CIBERER, Bioinformat Rare Dis BiER, FPS, Seville 41013, Spain
[4] Hosp Virgen del Rocio, FPS, ELIXIR Es, Seville 42013, Spain
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.1038/s41392-020-00417-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection
    Carlos Loucera
    Marina Esteban-Medina
    Kinza Rian
    Matías M. Falco
    Joaquín Dopazo
    María Peña-Chilet
    Signal Transduction and Targeted Therapy, 5
  • [2] Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing
    Glebov, Oleg O.
    FEBS JOURNAL, 2020, 287 (17) : 3664 - 3671
  • [3] A review of SARS-CoV-2 drug repurposing: databases and machine learning models
    Elkashlan, Marim
    Ahmad, Rahaf M.
    Hajar, Malak
    Al Jasmi, Fatma
    Corchado, Juan Manuel
    Nasarudin, Nurul Athirah
    Mohamad, Mohd Saberi
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [4] Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19
    Mirabelli, Carmen
    Wotring, Jesse W.
    Zhang, Charles J.
    McCarty, Sean M.
    Fursmidt, Reid
    Pretto, Carla D.
    Qiao, Yuanyuan
    Zhang, Yuping
    Frum, Tristan
    Kadambi, Namrata S.
    Amin, Anya T.
    O'Meara, Teresa R.
    Spence, Jason R.
    Huang, Jessie
    Alysandratos, Konstantinos D.
    Kotton, Darrell N.
    Handelman, Samuel K.
    Wobus, Christiane E.
    Weatherwax, Kevin J.
    Mashour, George A.
    O'Meara, Matthew J.
    Chinnaiyan, Arul M.
    Sexton, Jonathan Z.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (36)
  • [5] A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing
    Habibi, Mahnaz
    Taheri, Golnaz
    Aghdam, Rosa
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [6] Animal and translational models of SARS-CoV-2 infection and COVID-19
    Johansen, M. D.
    Irving, A.
    Montagutelli, X.
    Tate, M. D.
    Rudloff, I
    Nold, M. F.
    Hansbro, N. G.
    Kim, R. Y.
    Donovan, C.
    Liu, G.
    Faiz, A.
    Short, K. R.
    Lyons, J. G.
    McCaughan, G. W.
    Gorrell, M. D.
    Cole, A.
    Moreno, C.
    Couteur, D.
    Hesselson, D.
    Triccas, J.
    Neely, G. G.
    Gamble, J. R.
    Simpson, S. J.
    Saunders, B. M.
    Oliver, B. G.
    Britton, W. J.
    Wark, P. A.
    Nold-Petry, C. A.
    Hansbro, P. M.
    MUCOSAL IMMUNOLOGY, 2020, 13 (06) : 877 - 891
  • [7] Identifying COVID-19 Severity-Related SARS-CoV-2 Mutation Using a Machine Learning Method
    Huang, Feiming
    Chen, Lei
    Guo, Wei
    Zhou, Xianchao
    Feng, Kaiyan
    Huang, Tao
    Cai, Yudong
    LIFE-BASEL, 2022, 12 (06):
  • [8] Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
    Patocka, Jiri
    Kuca, Kamil
    Oleksak, Patrik
    Nepovimova, Eugenie
    Valis, Martin
    Novotny, Michal
    Klimova, Blanka
    PHARMACEUTICALS, 2021, 14 (03)
  • [9] Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights
    Wark, Peter A. B.
    Pathinayake, Prabuddha S.
    Eapen, Mathew Suji
    Sohal, Sukhwinder Singh
    EUROPEAN RESPIRATORY JOURNAL, 2021, 58 (02)
  • [10] SARS-CoV-2 Infection and COVID-19 in Children
    Waghmare, Alpana
    Hijano, Diego R.
    CLINICS IN CHEST MEDICINE, 2023, 44 (02) : 359 - 371
12345