Synthesis and Biological Evaluation of Cyanogenic Glycosides

被引：8

作者：

Yashunsky, Dmitry V. ^{[1
]}

Kulakovskaya, Ekaterina V. ^{[2
]}

Kulakovskaya, Tatiana V. ^{[2
]}

Zhukova, Olga S. ^{[2
]}

Kiselevskiy, Mikhail V. ^{[3
]}

Nifantiev, Nikolay E. ^{[1
]}

机构：

[1] Russian Acad Sci, Lab Glycoconjugate Chem, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

[2] Russian Acad Sci, Skryabin Inst Biochem & Physiol Microorganisms, Pushchino 142290, Moscow Region, Russia

[3] NN Blokhin Russian Canc Res Ctr, Lab Cell Immun, Moscow 115478, Russia

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2015年 / 34卷 / 08期

基金：

俄罗斯科学基金会;

关键词：

Cyanogenic glycosides; Glycosylation; Nitrile formation; Cytotoxic activity; Cancer cells; NITRIC-OXIDE SYNTHASE; EXPRESSIONS;

D O I：

10.1080/07328303.2015.1105249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient procedure for the synthesis of cyanogenic glycosides with different carbohydrate units was developed. Amygdalin (3), prunasin (1), sambunigrin (2), and neoamygdalin (21) were prepared according to the elaborated method, and biological tests, including antifungal, antibacterial, and cytotoxic activities, were performed.

引用

页码：460 / 474

页数：15

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