Effect of previous hormone replacement therapy on endometrial polyps during menopause

被引：5

作者：

Maia, H ^{[1
]}

Maltez, A ^{[1
]}

Studard, E ^{[1
]}

Athayde, C ^{[1
]}

Coutinho, EM ^{[1
]}

机构：

[1] CEPARH, Endoscopy Unit, Salvador, BA, Brazil

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2004年 / 18卷 / 06期

关键词：

endometrial polyps; hormone replacement therapy; menopause;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on the expression of Ki-67, bcl-2 and c-erb.B2 in endometrial polyps during menopause. Sixteen patients using HRT and 24 untreated controls with endometrial polyps were enrolled in this study. Polypectomy was carried out by hysteroscopy. The presence of c-erb.B2, bcl-2 and Ki-67 expression was determined by immunohistochemistry. HRT was found to decrease Ki- 67 and bcl-2 expression in endometrial polyps without affecting the c-erb. B2 staining reaction. HRT may cause endometrial polyp involution by decreasing proliferation and stimulating, apoptosis.

引用

收藏

页码：299 / 304

页数：6

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