Sulcal morphology as a new imaging marker for the diagnosis of early onset Alzheimer's disease

被引：37

作者：

Hamelin, Lorraine ^{[1
,2
]}

Bertoux, Maxime ^{[1
,2
,3
]}

Bottlaender, Michel ^{[4
,5
]}

Corne, Helene ^{[1
,2
]}

Lagarde, Julien ^{[1
]}

Hahn, Valerie ^{[1
]}

Mangin, Jean-Francois ^{[4
]}

Dubois, Bruno ^{[2
,6
]}

Chupin, Marie ^{[2
,7
,8
,9
,10
]}

de Souza, Leonardo Cruz ^{[11
]}

Colliot, Olivier ^{[2
,7
,8
,9
,10
]}

Sarazin, Marie ^{[1
]}

机构：

[1] Univ Paris 05, Ctr Hosp St Anne, Dept Neurol Memory & Language, Sorbonne Paris Cite,INSERM UMR S894, Paris, France

[2] ICM, Inst Cerveau & Moelle Epiniere, Paris, France

[3] Univ Cambridge, Dept Clin Neurosiences, Cambridge CB2 1TN, England

[4] CEA, NeuroSpin, Inst Imagerie Biomed, Direct Sci Vivant, Gif Sur Yvette, France

[5] CEA, Serv Hosp Frederic Joliot, Inst Imagerie Biomed, Lab Imagerie Mol In Vivo,UMR 1023,Direct Sci Viva, F-91406 Orsay, France

[6] Salpetriere Hosp, AP HP, Dept Neurol, Paris, France

[7] INSERM, U1127, Paris, France

[8] CNRS, UMR 7225, ICM, Paris, France

[9] Univ Paris 06, UMR S 1127, Univ Sorbonne, Paris, France

[10] Inria, Aramis Project Team, Ctr Rech Paris Rocquencourt, Paris, France

[11] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

来源：

NEUROBIOLOGY OF AGING | 2015年 / 36卷 / 11期

关键词：

Alzheimer's disease; MRI; Sulcal width; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; LONGITUDINAL CHANGES; NATIONAL INSTITUTE; AMNESTIC SYNDROME; HIPPOCAMPAL; ATROPHY; MRI; DEMENTIA; RECOMMENDATIONS;

D O I：

10.1016/j.neurobiolaging.2015.04.019

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We investigated the utility of sulcal width measures in the diagnosis of Alzheimer's disease (AD). Sixty-six biologically confirmed AD patients (positive amyloid positron emission tomography [PET] and/or AD cerebrospinal fluid profile) were contrasted to 35 controls with negative amyloid PET. Patients were classified into prodromal or dementia stages as well as into late onset (LOAD, n = 31) or early onset (EOAD, n = 35) subgroups according to their age of onset. An automated method was used to calculate sulcal widths and hippocampal volumes (HV). In EOAD, the greatest ability to differentiate patients from age-matched controls, regardless of severity, was displayed by sulcal width of the temporoparietal cortex. In this region, diagnosis accuracy was better than the HV, especially at prodromal stage. In LOAD, HV provided the best discrimination power from age-matched controls. In conclusion, sulcal width measures are better markers than the HV for identifying prodromal AD in patients aged <65 years. In contrast, in older patients, the risk of over-diagnosis from using only sulcal enlargement is important. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：2932 / 2939

页数：8

共 44 条

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