Structural determinants of efficacy for κ opioid receptors in the orvinol series:: 7,7-spiro analogues of buprenorphine

被引：23

作者：

Husbands, SM ^{[1
]}

Lewis, JW ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol, Avon, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 02期

关键词：

D O I：

10.1021/jm991165p

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：139 / 141

页数：3

共 10 条

[1] METHYLATION OF THE ENOLATES OF THEVINONE AND SOME ANALOGS
COOP, A
GRIVAS, K
HUSBANDS, S
LEWIS, JW
[J]. TETRAHEDRON, 1995, 51 (35) : 9681 - 9698
[2] RING CONSTRAINED ANALOGS OF THE THEVINONES - DIELS-ALDER REACTIONS OF THEBAINES WITH 1-INDENONE AND METHYLENE CYCLOALKANONES
COOP, A
GRIVAS, K
HUSBANDS, S
LEWIS, JW
PORTER, J
[J]. TETRAHEDRON LETTERS, 1995, 36 (10) : 1689 - 1692
[3] COOP A, 1995, NIDA RES MONOG, V153, P128
[4] Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists.
Husbands, SM
Lewis, JW
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (24) : 2969 - 2974
[5] Ring constrained analogues of the orvinols: The furanomorphides.
Husbands, SM
Breeden, SW
Grivas, K
Lewis, JW
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (06) : 831 - 834
[6] ANALGESICS OF THE ORVINOL TYPE - 19-DEOXY AND 6,20-EPOXY DERIVATIVES
HUTCHINS, CW
RAPOPORT, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) : 521 - 527
[7] Lewis John W., 1995, P3
[8] INTRA-MOLECULAR HYDROGEN-BONDING AND CONFORMATIONAL STUDIES OF BRIDGED THEBAINE AND ORIPAVINE OPIATE NARCOTIC AGONISTS AND ANTAGONISTS
LOEW, GH
BERKOWITZ, DS
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (06) : 603 - 607
[9] THE BINDING SPECTRUM OF NARCOTIC ANALGESIC DRUGS WITH DIFFERENT AGONIST AND ANTAGONIST PROPERTIES
MAGNAN, J
PATERSON, SJ
TAVANI, A
KOSTERLITZ, HW
[J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1982, 319 (03) : 197 - 205
[10] TRAYNOR JR, 1995, MOL PHARMACOL, V47, P848

← 1 →