Enzyme-catalyzed synthesis of (R)- and (S)-3-heteroaryl-3-hydroxy-propanoic acids and their derivatives

被引：18

作者：

Brem, Juergen ^{[1
]}

Paizs, Csaba ^{[1
]}

Tosa, Monica Ioana ^{[1
]}

Vass, Elemer ^{[2
]}

Irimie, Florin Dan ^{[1
]}

机构：

[1] Univ Babes Bolyai, Dept Biochem & Biochem Engn, R-3400 Cluj Napoca, Romania

[2] Eotvos Lorand Univ, Inst Chem, Lab Chiropt Struct Anal, H-1518 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 04期

基金：

匈牙利科学研究基金会;

关键词：

CANDIDA-PARAPSILOSIS ATCC-7330; KINETIC RESOLUTION; ENANTIOSELECTIVE REACTION; 3-HYDROXY ESTERS; TRANSESTERIFICATION; DERACEMISATION; REDUCTION; DIKETENE;

D O I：

10.1016/j.tetasy.2009.02.001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Starting from the racemic 3-benzofuranyl- and 3-benzo[b]thiophenyl-3-hydroxypropanoic acid ethyl esters as substrates, various multistep enzymatic procedures were developed for the efficient synthesis of the corresponding highly enantiomerically enriched (R)- and (S)-3-heteroaryl-3-hydroxypropanoic acids. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：489 / 496

页数：8

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