A Core Outcome Set for Pediatric Critical Care*

被引：95

作者：

Fink, Ericka L. ^{[1
]}

Maddux, Aline B. ^{[2
]}

Pinto, Neethi ^{[3
]}

Sorenson, Samuel ^{[4
]}

Notterman, Daniel ^{[5
]}

Dean, J. Michael ^{[4
]}

Carcillo, Joseph A. ^{[1
]}

Berg, Robert A. ^{[3
]}

Zuppa, Athena ^{[3
]}

Pollack, Murray M. ^{[6
]}

Meert, Kathleen L. ^{[7
]}

Hall, Mark W. ^{[8
]}

Sapru, Anil ^{[9
]}

McQuillen, Patrick S. ^{[10
]}

Mourani, Peter M. ^{[2
]}

Wessel, David ^{[6
]}

Amey, Deborah ^{[11
]}

Argent, Andrew ^{[12
,13
]}

de Carvalho, Werther Brunow ^{[14
]}

Butt, Warwick ^{[15
]}

Choong, Karen ^{[16
,17
]}

Curley, Martha A. Q. ^{[18
,19
]}

Lopez, Maria del Pilar Arias ^{[20
]}

Demirkol, Demet ^{[21
,22
]}

Grosskreuz, Ruth ^{[2
]}

Houtrow, Amy J. ^{[23
]}

Knoester, Hennie ^{[24
]}

Lee, Jan Hau ^{[25
]}

Long, Debbie ^{[26
]}

Manning, Joseph C. ^{[27
,28
]}

Morrow, Brenda ^{[12
]}

Sankar, Jhuma ^{[29
]}

Slomine, Beth S. ^{[30
,31
]}

Smith, McKenna ^{[4
]}

Olson, Lenora M. ^{[4
]}

Watson, R. Scott ^{[32
,33
]}

机构：

[1] UPMC Childrens Hosp Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15224 USA

[2] Univ Colorado, Childrens Hosp Colorado, Dept Pediat, Crit Care Med,Sch Med, Aurora, CO USA

[3] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA

[4] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA

[5] Princeton Univ, Dept Mol Biol, Princeton, NJ USA

[6] Childrens Natl Hosp, Dept Pediat, Washington, DC USA

[7] Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA

[8] Nationwide Childrens Hosp, Dept Pediat, Columbus, OH USA

[9] Univ Calif Los Angeles, Dept Pediat, Mattel Childrens Hosp, Los Angeles, CA 90024 USA

[10] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA USA

[11] Collaborat Pediat Crit Care Res Network, Family Collaborat, Great Falls, VA USA

[12] Univ Cape Town, Dept Paediat & Child Hlth, Cape Town, South Africa

[13] Red Cross War Mem Childrens Hosp, Cape Town, South Africa

[14] Univ Sao Paulo, Dept Pediat, Sao Paulo, Brazil

[15] Royal Childrens Hosp, Dept Paediat, Intens Care, Melbourne, Vic, Australia

[16] McMaster Univ, Dept Pediat, Hamilton, ON, Canada

[17] McMaster Univ, Dept Crit Care, Hamilton, ON, Canada

[18] Univ Penn, Dept Family & Community Hlth Nursing, Anesthesiol & Crit Care, Perelman Sch Med, Philadelphia, PA 19104 USA

[19] Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA

[20] Hosp Ninos Dr R Gutierrez, Dept Pediat Crit Care, Buenos Aires, DF, Argentina

[21] Istanbul Univ, Child Hlth Inst, Dept Pediat Intens Care, Istanbul, Turkey

[22] Istanbul Fac Med, Istanbul, Turkey

[23] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA USA

[24] Ctr Univ Amsterdam, Dept Paediat, Amsterdam, Netherlands

[25] KK Womens & Childrens Hosp, Dept Pediat Subspecial, Singapore, Singapore

[26] Queensland Univ Technol, Ctr Healthcare Transformat, Sch Nursing, Brisbane, Qld, Australia

[27] Univ Nottingham, Sch Hlth Sci, Children & Young People Hlth Res, Nottingham, England

[28] Nottingham Univ Hosp NHS Trust, Nottingham Childrens Hosp, Nottingham, England

[29] All India Inst Med Sci, Dept Pediat, Chandigarh, India

[30] Johns Hopkins Univ, Sch Med, Dept Neuropsychol, Kennedy Krieger Inst, Baltimore, MD USA

[31] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[32] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

[33] Seattle Childrens Res Inst, Ctr Child Hlth Behav & Dev, Seattle, WA USA

来源：

CRITICAL CARE MEDICINE | 2020年 / 48卷 / 12期

关键词：

child; critical care; family; outcome assessment; postintensive care syndrome; RESPIRATORY-FAILURE SURVIVORS; QUALITY-OF-LIFE; INTENSIVE-CARE; CLINICAL-RESEARCH; RISK-FACTORS; CHILDREN; CONSENSUS;

D O I：

10.1097/CCM.0000000000004660

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objectives: More children are surviving critical illness but are at risk of residual or new health conditions. An evidence-informed and stakeholder-recommended core outcome set is lacking for pediatric critical care outcomes. Our objective was to create a multinational, multistakeholder-recommended pediatric critical care core outcome set for inclusion in clinical and research programs. Design: A two-round modified Delphi electronic survey was conducted with 333 invited research, clinical, and family/advocate stakeholders. Stakeholders completing the first round were invited to participate in the second. Outcomes scoring greater than 69% "critical" and less than 15% "not important" advanced to round 2 with write-in outcomes considered. The Steering Committee held a virtual consensus conference to determine the final components. Setting: Multinational survey. Patients: Stakeholder participants from six continents representing clinicians, researchers, and family/advocates. Measurements and Main Results: Overall response rates were 75% and 82% for each round. Participants voted on seven Global Domains and 45 Specific Outcomes in round 1, and six Global Domains and 30 Specific Outcomes in round 2. Using overall (three stakeholder groups combined) results, consensus was defined as outcomes scoring greater than 90% "critical" and less than 15% "not important" and were included in the final PICU core outcome set: four Global Domains (Cognitive, Emotional, Physical, and Overall Health) and four Specific Outcomes (Child Health-Related Quality of Life, Pain, Survival, and Communication). Families (n = 21) suggested additional critically important outcomes that did not meet consensus, which were included in the PICU core outcome set-extended. Conclusions: The PICU core outcome set and PICU core outcome set-extended are multistakeholder-recommended resources for clinical and research programs that seek to improve outcomes for children with critical illness and their families.

引用

页码：1819 / 1828

页数：10

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