Incidence of Cancer Following Bariatric Surgery: Systematic Review and Meta-analysis

被引：65

作者：

Casagrande, Daniela Schaan ^{[1
,2
]}

Rosa, Daniela Dornelles ^{[3
]}

Umpierre, Daniel ^{[4
]}

Sarmento, Roberta Aguiar ^{[1
]}

Rodrigues, Clarissa Garcia ^{[5
,6
]}

Schaan, Beatriz D. ^{[1
,4
]}

机构：

[1] Univ Fed Rio Grande do Sul, Postgrad Program Med Sci Endocrinol & Metab, Hosp Clin Porto Alegre, BR-90035003 Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande Sul COM HSL P, Obes & Metab Syndrome Ctr, Hosp Sao Lucas, Porto Alegre, RS, Brazil

[3] Hosp Moinhos Vento, Oncol Unit, Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Postgrad Program Hlth Sci Cardiovasc Sci, Porto Alegre, RS, Brazil

[5] Fundacao Univ Cardiol, Inst Cardiol Rio Grande Sul IC FUC, Porto Alegre, RS, Brazil

[6] Duke Univ, Duke Global Hlth Inst DGHI, Durham, NC USA

来源：

OBESITY SURGERY | 2014年 / 24卷 / 09期

关键词：

Cancer; Morbid obesity; Bariatric surgery; Gastric bypass; BODY-MASS INDEX; LONG-TERM MORTALITY; HEALTH-CARE USE; GASTRIC BYPASS; OBESITY SURGERY; WEIGHT-LOSS; RISK; SWEDEN; INFLAMMATION; OVERWEIGHT;

D O I：

10.1007/s11695-014-1276-0

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Obesity is linked to the development of cancer. Previous studies have suggested that there is a relationship between bariatric surgery and reduced cancer risk. Data sources were from Medline, Embase, and Cochrane Library. From 951 references, 13 studies met the inclusion criteria (54,257 participants). In controlled studies, bariatric surgery was associated with a reduction in the risk of cancer. The cancer incidence density rate was 1.06 cases per 1000 person-years within the surgery groups. In the meta-regression, we found an inverse relationship between the presurgical body mass index and cancer incidence after surgery (beta coefficient -0.2, P < 0.05). Bariatric surgery is associated with reduced cancer risk in morbidly obese people. However, considering the heterogeneity among the studies, conclusions should be drawn with care.

引用

页码：1499 / 1509

页数：11

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