Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain

被引：55

作者：

Grau-Perez, Maria ^{[1
,2
,3
]}

Navas-Acien, Ana ^{[3
,4
]}

Galan-Chilet, Inmaculada ^{[5
]}

Briongos-Figuero, Laisa S. ^{[6
]}

Morchon-Simon, David ^{[6
]}

Bermudez, Jose D. ^{[2
]}

Crainiceanu, Ciprian M. ^{[7
]}

de Marco, Griselda ^{[5
]}

Rentero-Garrido, Pilar ^{[5
]}

Garcia-Barrera, Tamara ^{[8
]}

Gomez-Ariza, Jose L. ^{[8
]}

Casasnovas, Jose A. ^{[9
]}

Martin-Escudero, Juan C. ^{[6
]}

Redon, Josep ^{[1
,10
,11
]}

Javier Chaves, F. ^{[5
,12
]}

Tellez-Plaza, Maria ^{[1
,4
]}

机构：

[1] Hosp Clin Valencia INCLIVA, Area Cardiometab & Renal Risk, Biomed Res Inst, Valencia, Spain

[2] Univ Valencia, Dept Stat & Operat Res, Valencia, Spain

[3] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth & Engn, New York, NY USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA

[5] Hosp Clin Valencia INCLIVA, Genom & Genet Diag Unit, Biomed Res Inst, Valencia, Spain

[6] Univ Hosp Rio Hortega, Dept Internal Med, Valladolid, Spain

[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[8] Univ Huelva, Dept Chem, Huelva, Spain

[9] CIBER Cardiovasc CIBERCV, Inst Invest Sanitaria Aragon, Unidad Invest Prevenc Cardiovasc, Zaragoza, Spain

[10] Minister Hlth, Inst Hlth Carlos III, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain

[11] Hosp Clin Valencia, Dept Internal Med, Valencia, Spain

[12] CIBER Diabet & Associated Metab Dis CIBERDEM, Barcelona, Spain

来源：

ENVIRONMENTAL POLLUTION | 2018年 / 235卷

关键词：

Arsenic; Diabetes; Arsenic species; Gene-environment interaction; Multiple imputation; DRINKING-WATER; LOW-LEVEL; GENDER-DIFFERENCES; THIOREDOXIN; HEALTH; ASSOCIATION; NEUTROPHILS; EXPRESSION; DISEASE; LIGASE;

D O I：

10.1016/j.envpol.2018.01.008

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 mu g/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：948 / 955

页数：8

共 46 条

[31] Seafood intake and urine concentrations of total arsenic, dimethylarsinate and arsenobetaine in the US population [J].